Quinolizidine alkaloids from Sophora alopecuroides with anti-inflammatory and anti-tumor properties.
Animals
Anti-Inflammatory Agents
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Line, Tumor
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Lipopolysaccharides
/ antagonists & inhibitors
Mice
Molecular Docking Simulation
Molecular Structure
Nitric Oxide
/ antagonists & inhibitors
Quinolizidines
/ chemistry
RAW 264.7 Cells
Sophora
/ chemistry
Structure-Activity Relationship
Anti-inflammatory
Anti-tumor
Leguminosae
Quinolizidine alkaloids
Sophora alopecuroides
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
03
11
2020
revised:
20
01
2021
accepted:
22
02
2021
pubmed:
8
3
2021
medline:
13
10
2021
entrez:
7
3
2021
Statut:
ppublish
Résumé
Forty-three quinolizidine alkaloids (1-43), including twelve new matrine-type ones, sophalodes A-L (1-7, 17, 19 and 28-30), were isolated from the seeds of Sophora alopecuroides. Structurally, compounds 1-4 were the first examples of C-11 oxidized matrine-type alkaloids from Sophora plants. The structures and absolute configurations of new compounds were elucidated by extensive spectroscopic techniques, X-ray diffraction analysis, and quantum chemical calculation. In addition, the NMR data and absolute configuration of compound 18 was reported for the first time. All the isolates were evaluated for their inhibition on nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophages, among them, compounds 29, 38 and 42 exhibited the most significant activity with IC
Identifiants
pubmed: 33677246
pii: S0045-2068(21)00158-9
doi: 10.1016/j.bioorg.2021.104781
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antineoplastic Agents, Phytogenic
0
Lipopolysaccharides
0
Quinolizidines
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104781Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.