Late-onset MS is associated with an increased rate of reaching disability milestones.
Ageing
Disability
Late-onset
Multiple sclerosis
Real-word studies
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
18
11
2020
accepted:
22
02
2021
revised:
20
02
2021
pubmed:
8
3
2021
medline:
14
8
2021
entrez:
7
3
2021
Statut:
ppublish
Résumé
To describe patient characteristics and assess the risk of disability worsening in patients of different age groups with focus on late-onset multiple sclerosis (LOMS) defined as disease onset after the age of 50 years. The nationwide population-based Danish Multiple Sclerosis Registry served as data source. We described baseline characteristics and analyzed rates of reaching Expanded Disability Status Scale (EDSS) milestones. We identified 28,232 patients with MS with a known year of clinical onset, of which 2661 had LOMS. The LOMS group had a higher proportion of males and patients with primary progressive disease course, and they were less likely to receive disease-modifying therapy. The initial rate of reaching EDSS milestone 6 after diagnosis was higher in LOMS [hazard ratio (HR) 1.53; 95% confidence interval (CI) 1.14-2.06]; however, when assessing the risk of reaching EDSS 6 according to age, the HR was significantly lower for the LOMS group (HR 0.307; 95% CI 0.221-0.426). The clinical characteristics and treatment approaches for patients with LOMS differ from their younger counterparts. Following diagnosis, patients with LOMS initially have an increased rate of reaching EDSS score 6; however, the risk of reaching EDSS score 6 at any given age is higher in patients with non-LOMS.
Identifiants
pubmed: 33677675
doi: 10.1007/s00415-021-10490-0
pii: 10.1007/s00415-021-10490-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3352-3360Informations de copyright
© 2021. Springer-Verlag GmbH, DE part of Springer Nature.
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