Selective Autophagy Receptors in Antiviral Defense.
antiviral immunity
autophagy receptors
cell autonomous defense
selective autophagy
viral infection
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
02
12
2020
revised:
08
02
2021
accepted:
10
02
2021
pubmed:
9
3
2021
medline:
15
12
2021
entrez:
8
3
2021
Statut:
ppublish
Résumé
Autophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes and route them to elongating autophagic membranes, a process referred to as selective autophagy. Besides contributing to cell homeostasis, selective autophagy constitutes an important cell-autonomous defense mechanism against viruses. We review observations related to selective autophagy receptor engagement during host cell responses to virus infection. We examine the distinct roles of autophagy receptors in antiviral autophagy, consider the strategies viruses have evolved to escape or oppose such restrictions, and delineate the contributions of selective autophagy to the tailoring of antiviral innate responses. Finally, we mention some open and emerging questions in the field.
Identifiants
pubmed: 33678557
pii: S0966-842X(21)00042-1
doi: 10.1016/j.tim.2021.02.006
pii:
doi:
Substances chimiques
Receptors, Virus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
798-810Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests No interests are declared.