Repetitive Transcranial Magnetic Stimulation With H-Coil in Alzheimer's Disease: A Double-Blind, Placebo-Controlled Pilot Study.
ADAS-cog
Alzheimer's disease
H-coil
neuromodualtion
repetitive transcranial magnetic stimulation
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
10
2020
accepted:
16
12
2020
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
9
3
2021
Statut:
epublish
Résumé
Focal repetitive transcranial magnetic stimulation (rTMS) has been applied to improve cognition in Alzheimer's disease (AD) with conflicting results. We applied rTMS in AD in a pilot placebo-controlled study using the H2-coil. H-coils are suitable for targeting wider neuronal structures compared with standard focal coils, in particular the H2-coil stimulates simultaneously the frontal-parietal-temporal lobes bilaterally. Thirty patients (mean age 70.9 year, SD 8.1; mean MMSE score 16.9, SD 5.5) were randomized to sham or real 10 Hz rTMS stimulation with the H2-coil. Each patient underwent 3 sessions/week for 4 weeks, followed by 4 weeks with maintenance treatment (1 session/week). Primary outcome was improvement of ADAS-cog at 4 and 8 weeks compared with baseline. A trend toward an improved ADAS-cog score over time was observed for patients undergoing real rTMS, with actively treated patients experiencing a mean decrease of -1.01 points at the ADAS-Cog scale score per time point (95% CIs -0.02 to -3.13,
Identifiants
pubmed: 33679572
doi: 10.3389/fneur.2020.614351
pmc: PMC7930223
doi:
Banques de données
ClinicalTrials.gov
['NCT04562506']
Types de publication
Case Reports
Langues
eng
Pagination
614351Informations de copyright
Copyright © 2021 Leocani, Dalla Costa, Coppi, Santangelo, Pisa, Ferrari, Bernasconi, Falautano, Zangen, Magnani and Comi.
Déclaration de conflit d'intérêts
AZ was a key inventor of H-coli and acts as a consultant for Brainsway Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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