Endogenous Long Pentraxin 3 Exerts a Protective Role in a Murine Model of Pulmonary Fibrosis.
bleomycin
fibroblast
immune infiltrate
long pentraxin-3
lung fibrosis
stroma
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
10
2020
accepted:
11
01
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Pulmonary fibrosis is a progressive scarring disease of the lungs, characterized by inflammation, fibroblast activation, and deposition of extracellular matrix. The long pentraxin 3 (PTX3) is a member of the pentraxin family with non-redundant functions in innate immune responses, tissue repair, and haemostasis. The role played in the lungs by PTX3 during the fibrotic process has not been elucidated. In this study, the impact of PTX3 expression on lung fibrosis was assessed in an intratracheal bleomycin (BLM)-induced murine model of the disease applied to wild type animals, transgenic mice characterized by endothelial overexpression and stromal accumulation of PTX3 (Tie2-PTX3 mice), and genetically deficient
Identifiants
pubmed: 33679758
doi: 10.3389/fimmu.2021.617671
pmc: PMC7930377
doi:
Substances chimiques
Biomarkers
0
Serum Amyloid P-Component
0
Bleomycin
11056-06-7
PTX3 protein
148591-49-5
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
617671Informations de copyright
Copyright © 2021 Maccarinelli, Bugatti, Churruca Schuind, Ganzerla, Vermi, Presta and Ronca.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Am J Respir Crit Care Med. 2002 May 1;165(9):1205-6
pubmed: 11991866
J Biol Chem. 2017 Jun 23;292(25):10364-10378
pubmed: 28487375
Oncotarget. 2017 Aug 1;8(47):82583-82592
pubmed: 29137286
J Infect Dis. 2013 Jul;208(1):130-8
pubmed: 23087427
Respir Res. 2010 Oct 04;11:134
pubmed: 20920344
PLoS Pathog. 2015 Feb 19;11(2):e1004649
pubmed: 25695775
Int J Exp Pathol. 2002 Jun;83(3):111-9
pubmed: 12383190
PLoS One. 2010 Mar 12;5(3):e9683
pubmed: 20300636
J Immunol. 2011 May 1;186(9):5425-34
pubmed: 21441447
Am J Pathol. 2002 May;160(5):1755-65
pubmed: 12000727
Nature. 2002 Nov 14;420(6912):182-6
pubmed: 12432394
Antimicrob Agents Chemother. 2004 Nov;48(11):4414-21
pubmed: 15504871
Am J Respir Cell Mol Biol. 2008 Sep;39(3):324-36
pubmed: 18403781
Clin Cancer Res. 2011 Apr 15;17(8):2395-9
pubmed: 21257721
Cancer Treat Rev. 1983 Dec;10(4):221-43
pubmed: 6198083
Am J Pathol. 1979 Apr;95(1):117-30
pubmed: 86304
J Exp Med. 2017 Aug 7;214(8):2387-2404
pubmed: 28694385
Respir Med Res. 2020 Mar;77:72-78
pubmed: 32416587
Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708
pubmed: 15951334
Eur Cytokine Netw. 2009 Jun;20(2):39-50
pubmed: 19541589
Mediators Inflamm. 2013;2013:725102
pubmed: 23690668
Biochim Biophys Acta Rev Cancer. 2018 Jan;1869(1):53-63
pubmed: 29175552
Cell. 2015 Feb 12;160(4):700-714
pubmed: 25679762
Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81
pubmed: 21680953
Semin Liver Dis. 2010 Aug;30(3):245-57
pubmed: 20665377
Mol Diagn Ther. 2020 Dec;24(6):665-681
pubmed: 32926347
Nat Rev Immunol. 2011 Jun;11(6):427-35
pubmed: 21597472
Int J Mol Sci. 2019 Sep 17;20(18):
pubmed: 31533326
Lab Invest. 2012 Sep;92(9):1285-96
pubmed: 22732935
Am Rev Respir Dis. 1978 Jun;117(6):1099-108
pubmed: 78675
Am J Pathol. 1995 Dec;147(6):1759-69
pubmed: 7495300
J Exp Med. 2007 Apr 16;204(4):793-804
pubmed: 17389238
Am Rev Respir Dis. 1980 Mar;121(3):501-6
pubmed: 6158281
Am J Respir Crit Care Med. 2006 Apr 1;173(7):781-92
pubmed: 16415274
Semin Immunol. 2013 Feb;25(1):79-85
pubmed: 23747040
Respir Med. 2006 Feb;100(2):340-7
pubmed: 16002271
PLoS One. 2015 Mar 16;10(3):e0119709
pubmed: 25774777
PLoS One. 2012;7(4):e34965
pubmed: 22529962
Semin Immunol. 2016 Dec;28(6):570-577
pubmed: 27881292
Cancer Cell. 2015 Aug 10;28(2):225-39
pubmed: 26267536
Front Immunol. 2013 May 31;4:127
pubmed: 23755050
Clin Transl Immunology. 2019 Nov 05;8(11):e1086
pubmed: 31709050
Am J Respir Crit Care Med. 2002 May 1;165(9):1206-7; discussion 1207-8
pubmed: 11991867
Mol Cell Proteomics. 2012 Jun;11(6):M111.015073
pubmed: 22278372
J Immunol. 2005 Dec 15;175(12):8303-11
pubmed: 16339571
Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L152-60
pubmed: 17993587
Toxicol Sci. 2019 Apr 1;168(2):287-301
pubmed: 30590802
J Nucl Med. 2005 Sep;46(9):1421-6
pubmed: 16157523
Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824
pubmed: 21471066
N Engl J Med. 2012 May 24;366(21):1968-77
pubmed: 22607134
Nat Immunol. 2010 Apr;11(4):328-34
pubmed: 20208538
Cancers (Basel). 2019 Aug 30;11(9):
pubmed: 31480336
Blood. 2010 Dec 9;116(24):5170-80
pubmed: 20829368
J Natl Cancer Inst. 2017 Aug 1;109(8):
pubmed: 28376190
J Immunol. 2008 Dec 15;181(12):8433-40
pubmed: 19050261
Front Immunol. 2018 Oct 08;9:2327
pubmed: 30349543
J Exp Med. 2015 Jun 1;212(6):905-25
pubmed: 25964372
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
J Immunol. 2007 Sep 15;179(6):4035-44
pubmed: 17785842
N Engl J Med. 2018 Aug 23;379(8):797-798
pubmed: 30134133
Ann N Y Acad Sci. 2013 May;1285:1-14
pubmed: 23527487
Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1039-49
pubmed: 17277044
Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L144-53
pubmed: 16936248
Immunity. 2016 Mar 15;44(3):582-596
pubmed: 26921108
Trends Mol Med. 2016 Jun;22(6):497-510
pubmed: 27179743
Med Sci (Basel). 2018 Nov 29;6(4):
pubmed: 30501130
Front Immunol. 2019 Apr 04;10:712
pubmed: 31019517