No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis.
GWAS
Mendelian randomization
UK Biobank
cardiovascular risk
exercise
heart rate
recovery
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
06
2020
accepted:
08
01
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
9
3
2021
Statut:
epublish
Résumé
Reduced heart rate (HR) increase (HRI), recovery (HRR), and higher resting HR are associated with cardiovascular (CV) disease, but causal inferences have not been deduced. We investigated causal effects of HRI, HRR, and resting HR on CV risk, all-cause mortality (ACM), atrial fibrillation (AF), coronary artery disease (CAD), and ischemic stroke (IS) using Mendelian Randomization. 11 variants for HRI, 11 for HRR, and two sets of 46 and 414 variants for resting HR were obtained from four genome-wide association studies (GWASs) on UK Biobank. We performed a lookup on GWASs for CV risk and ACM in UK Biobank ( IVW showed a nominally significant effect of HRI on CV events (odds ratio [OR] = 1.0012, Our findings suggest no strong evidence of an association between HRI and HRR and any outcome and confirm prior work reporting a highly significant effect of resting HR on AF. Future research is required to explore HRI and HRR associations further using more powerful predictors, when available.
Sections du résumé
BACKGROUND
BACKGROUND
Reduced heart rate (HR) increase (HRI), recovery (HRR), and higher resting HR are associated with cardiovascular (CV) disease, but causal inferences have not been deduced. We investigated causal effects of HRI, HRR, and resting HR on CV risk, all-cause mortality (ACM), atrial fibrillation (AF), coronary artery disease (CAD), and ischemic stroke (IS) using Mendelian Randomization.
METHODS
METHODS
11 variants for HRI, 11 for HRR, and two sets of 46 and 414 variants for resting HR were obtained from four genome-wide association studies (GWASs) on UK Biobank. We performed a lookup on GWASs for CV risk and ACM in UK Biobank (
RESULTS
RESULTS
IVW showed a nominally significant effect of HRI on CV events (odds ratio [OR] = 1.0012,
CONCLUSION
CONCLUSIONS
Our findings suggest no strong evidence of an association between HRI and HRR and any outcome and confirm prior work reporting a highly significant effect of resting HR on AF. Future research is required to explore HRI and HRR associations further using more powerful predictors, when available.
Identifiants
pubmed: 33679875
doi: 10.3389/fgene.2021.569323
pmc: PMC7931909
doi:
Types de publication
Journal Article
Langues
eng
Pagination
569323Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/1996001/9454
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N025083/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/18/50/33837
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/20/18/35058
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Mensah-Kane, Schmidt, Hingorani, Finan, Chen, van Duijvenboden, Orini, Lambiase, Tinker, Marouli, Munroe and Ramírez.
Déclaration de conflit d'intérêts
AS has received unrestricted funding from Servier. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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