Case Report: Whole Exome Sequencing Revealed Disease-Causing Variants in Two Genes in a Patient With Autism Spectrum Disorder, Intellectual Disability, Hyperactivity, Sleep and Gastrointestinal Disturbances.

ORVAL attention deficit disorder and hyperactivity autism spectrum disorder gut motility disorders oligenic disease sleep disturbance whole exome sequencing

Journal

Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621

Informations de publication

Date de publication:
2021
Historique:
received: 03 11 2020
accepted: 19 01 2021
entrez: 8 3 2021
pubmed: 9 3 2021
medline: 9 3 2021
Statut: epublish

Résumé

Autism Spectrum Disorder (ASD) refers to a broad range of conditions characterized by difficulties in communication, social interaction and behavior, and may be accompanied by other medical or psychiatric conditions. Patients with ASD and comorbidities are often difficult to diagnose because of the tendency to consider the multiple symptoms as the presentation of a complicated syndromic form. This view influences variant filtering which might ignore causative variants for specific clinical features shown by the patient. Here we report on a male child diagnosed with ASD, showing cognitive and motor impairments, stereotypies, hyperactivity, sleep, and gastrointestinal disturbances. The analysis of whole exome sequencing (WES) data with bioinformatic tools for oligogenic diseases helped us to identify two major previously unreported pathogenetic variants: a maternally inherited missense variant (p.R4122H) in

Identifiants

pubmed: 33679889
doi: 10.3389/fgene.2021.625564
pmc: PMC7930735
doi:

Types de publication

Case Reports

Langues

eng

Pagination

625564

Informations de copyright

Copyright © 2021 Cerminara, Spirito, Pisciotta, Squillario, Servetti, Divizia, Lerone, Berloco, Boeri, Nobili, Vozzi, Sanges, Gustincich and Puliti.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Maria Cerminara (M)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

Giovanni Spirito (G)

Neuroscience Area, International School for Advanced Studies (SISSA), Trieste, Italy.

Livia Pisciotta (L)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Child Neuropsychiatry Unit, Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco (ASST Fbf Sacco), Milan, Italy.

Margherita Squillario (M)

Medical Genetics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Martina Servetti (M)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Medical Genetics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Maria Teresa Divizia (MT)

Medical Genetics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Margherita Lerone (M)

Medical Genetics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Bianca Berloco (B)

Child Neuropsychiatry Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Silvia Boeri (S)

Child Neuropsychiatry Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Lino Nobili (L)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Child Neuropsychiatry Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Diego Vozzi (D)

Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy.

Remo Sanges (R)

Neuroscience Area, International School for Advanced Studies (SISSA), Trieste, Italy.
Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy.

Stefano Gustincich (S)

Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy.

Aldamaria Puliti (A)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Medical Genetics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.

Classifications MeSH