Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria.
Antifungal
Antivirulence
Biosynthetic gene clusters
Fungal pathogens
Natural products
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
10
2020
revised:
02
02
2021
accepted:
02
02
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
9
3
2021
Statut:
epublish
Résumé
Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever-increasing number of fungal strains that have acquired resistance. In nature, bacteria and fungi display versatile interactions that range from friendly co-existence to predation. The first antifungal drugs, nystatin and amphotericin B, were discovered in bacteria as mediators of such interactions, and bacteria continue to be an important source of antifungals. To learn more about the ecological bacterial-fungal interactions that drive the evolution of natural products and exploit them, we need to identify environments where such interactions are pronounced, and diverse. Here, we systematically analyze historic and recent developments in this field to identify potentially under-investigated niches and resources. We also discuss alternative strategies to treat fungal infections by utilizing the antagonistic potential of bacteria to target fungal stress pathways and virulence factors, and thereby suppress the evolution of antifungal resistance.
Identifiants
pubmed: 33680363
doi: 10.1016/j.csbj.2021.02.003
pii: S2001-0370(21)00054-4
pmc: PMC7905183
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1244-1252Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Nat Protoc. 2008;3(8):1261-9
pubmed: 18714294
PLoS Pathog. 2009 Aug;5(8):e1000471
pubmed: 19714223
ISME J. 2012 Jun;6(6):1260-72
pubmed: 22189493
Mol Microbiol. 2004 Dec;54(5):1212-23
pubmed: 15554963
Cell. 2002 Mar 8;108(5):583-6
pubmed: 11893328
J Antibiot (Tokyo). 1970 Sep;23(9):442-7
pubmed: 5459626
Front Microbiol. 2012 Aug 08;3:286
pubmed: 23024638
PLoS Comput Biol. 2014 Dec 04;10(12):e1004016
pubmed: 25474254
J Biol Chem. 1999 Apr 9;274(15):10133-9
pubmed: 10187796
Cell. 1995 Aug 11;82(3):507-22
pubmed: 7543369
Antimicrob Agents Chemother. 1997 Jan;41(1):156-61
pubmed: 8980772
Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13173-7
pubmed: 23161559
Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4601-8
pubmed: 18216259
J Nat Prod. 2016 Mar 25;79(3):629-61
pubmed: 26852623
Antimicrob Agents Chemother. 2009 Jun;53(6):2517-21
pubmed: 19349517
Cell Microbiol. 2016 Sep;18(9):1308-16
pubmed: 27354115
Open Forum Infect Dis. 2019 Mar 15;6(Suppl 1):S79-S94
pubmed: 30895218
Eukaryot Cell. 2006 Dec;5(12):2184-8
pubmed: 17056742
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6733-8
pubmed: 21368185
Clin Infect Dis. 2016 May 1;62(9):1143-53
pubmed: 26826375
Appl Environ Microbiol. 2002 May;68(5):2391-6
pubmed: 11976113
Trends Microbiol. 2017 Mar;25(3):217-228
pubmed: 27916383
Open Forum Infect Dis. 2020 Jan 12;7(2):ofaa016
pubmed: 32099843
Nat Chem Biol. 2014 Nov;10(11):963-8
pubmed: 25262415
Curr Opin Microbiol. 2004 Oct;7(5):492-8
pubmed: 15451504
Antibiot Annu. 1955-1956;3:579-86
pubmed: 13355330
Front Microbiol. 2017 Aug 22;8:1593
pubmed: 28878752
BMC Genomics. 2013 Sep 11;14:611
pubmed: 24020438
Science. 2020 Nov 20;370(6519):974-978
pubmed: 33214279
Annu Rev Microbiol. 1985;39:321-46
pubmed: 3904603
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2818-23
pubmed: 19196973
Curr Opin Microbiol. 2016 Aug;32:89-95
pubmed: 27257746
Clin Infect Dis. 2017 Jan 15;64(2):134-140
pubmed: 27988485
mBio. 2017 Oct 3;8(5):
pubmed: 28974618
FEMS Microbiol Lett. 2020 Aug 1;367(15):
pubmed: 32710776
Nat Rev Microbiol. 2020 Jun;18(6):319-331
pubmed: 32047294
Curr Opin Microbiol. 2005 Apr;8(2):208-15
pubmed: 15802254
Antimicrob Agents Chemother. 2009 Dec;53(12):5026-34
pubmed: 19786600
Appl Environ Microbiol. 2002 Aug;68(8):3878-85
pubmed: 12147485
Int J Med Microbiol. 2014 Jan;304(1):3-13
pubmed: 24119567
F1000Res. 2018 Mar 5;7:272
pubmed: 29707201
Appl Microbiol Biotechnol. 2017 Jan;101(2):533-543
pubmed: 27554496
Curr Opin Microbiol. 2018 Oct;45:70-76
pubmed: 29547801
Science. 2002 May 10;296(5570):1127-9
pubmed: 12004133
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3655-6
pubmed: 24554079
J Antibiot (Tokyo). 1988 Nov;41(11):1586-91
pubmed: 3198493
Science. 2015 Mar 27;347(6229):1414-6
pubmed: 25814567
Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2:14555-61
pubmed: 12970466
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14558-63
pubmed: 19666480
Antimicrob Agents Chemother. 2018 Oct 24;62(11):
pubmed: 30181374
Nat Methods. 2019 Dec;16(12):1306-1314
pubmed: 31686038
Appl Environ Microbiol. 2008 Sep;74(17):5571-4
pubmed: 18606793
J Fungi (Basel). 2019 Apr 12;5(2):
pubmed: 31013706
Nat Prod Rep. 2014 Jul;31(7):953-72
pubmed: 24841474
Microbiome. 2018 Jan 15;6(1):12
pubmed: 29335027
Science. 2002 Jun 21;296(5576):2229-32
pubmed: 12077418
Nucleic Acids Res. 2008 Oct;36(17):e113
pubmed: 18701643
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4507-4512
pubmed: 28396417
Nat Chem Biol. 2014 May;10(5):400-6
pubmed: 24681535
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4742-6
pubmed: 19270078
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5970-5
pubmed: 27140646
Chem Biol. 2005 Mar;12(3):349-56
pubmed: 15797219
Annu Rev Microbiol. 2020 Sep 8;74:267-290
pubmed: 32660387
J Bacteriol. 2011 Sep;193(18):4626-33
pubmed: 21764930
Nat Commun. 2019 Jan 31;10(1):516
pubmed: 30705269
FEMS Microbiol Ecol. 2020 Jan 1;96(1):
pubmed: 31769789
Science. 2005 Sep 30;309(5744):2185-9
pubmed: 16195452
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5096
pubmed: 27512033
J Antibiot (Tokyo). 1977 May;30(5):371-5
pubmed: 407203
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9
pubmed: 22308411
Mar Drugs. 2017 Sep 01;15(9):
pubmed: 28862674
Cell Host Microbe. 2016 Jun 8;19(6):865-73
pubmed: 27237365
Arch Microbiol. 1976 Mar 19;107(2):143-60
pubmed: 1259515
Antonie Van Leeuwenhoek. 2017 Apr;110(4):593-605
pubmed: 28040855
Chem Biol. 2001 Jul;8(7):713-23
pubmed: 11451671
Nat Rev Drug Discov. 2017 Sep;16(9):603-616
pubmed: 28496146
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12809-12814
pubmed: 27791100
Microbiol Mol Biol Rev. 2011 Dec;75(4):583-609
pubmed: 22126995
Int J Syst Bacteriol. 1999 Oct;49 Pt 4:1577-89
pubmed: 10555339
Prog Drug Res. 2008;65:119, 121-40
pubmed: 18084914
Nat Commun. 2019 Oct 24;10(1):4841
pubmed: 31649246
Virulence. 2017 Feb 17;8(2):186-197
pubmed: 27325145
Microbiome. 2020 Sep 12;8(1):133
pubmed: 32919472
Science. 1950 Oct 13;112(2911):423
pubmed: 14781786
mBio. 2020 Jun 16;11(3):
pubmed: 32546614
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3757-62
pubmed: 24550451
Front Microbiol. 2019 Feb 26;10:353
pubmed: 30863389
Microbiology (Reading). 2004 Aug;150(Pt 8):2761-2774
pubmed: 15289572
Nature. 2002 May 9;417(6885):141-7
pubmed: 12000953
Nat Rev Microbiol. 2010 May;8(5):340-9
pubmed: 20348933
Appl Environ Microbiol. 2005 Sep;71(9):5544-50
pubmed: 16151147
Bull World Health Organ. 2001;79(8):780-90
pubmed: 11545337
Syst Rev. 2016 May 23;5:87
pubmed: 27216467
Chem Soc Rev. 2020 Apr 21;49(8):2426-2480
pubmed: 32140691
PLoS Comput Biol. 2017 Feb 21;13(2):e1005404
pubmed: 28222096
Cell. 2014 Jul 17;158(2):412-421
pubmed: 25036635
J Clin Microbiol. 1994 Feb;32(2):525-7
pubmed: 8150966
J Bacteriol. 2012 Aug;194(16):4151-60
pubmed: 22661685
Appl Microbiol Biotechnol. 2016 Feb;100(3):1285-1295
pubmed: 26497174
ISME J. 2019 Sep;13(9):2223-2235
pubmed: 31065029
Annu Rev Microbiol. 2013;67:375-97
pubmed: 23808337
Pharmaceuticals (Basel). 2019 Dec 12;12(4):
pubmed: 31842280
Antimicrob Agents Chemother. 2014;58(3):1458-67
pubmed: 24366729
Nat Rev Immunol. 2017 Oct;17(10):635-646
pubmed: 28604735
Nat Rev Microbiol. 2007 Jun;5(6):418-30
pubmed: 17505522
Mol Phylogenet Evol. 2010 Nov;57(2):878-87
pubmed: 20807581
Nat Prod Rep. 2016 Aug 27;33(8):988-1005
pubmed: 27272205
Chem Biol. 2000 Jun;7(6):395-403
pubmed: 10873841
Nat Chem Biol. 2009 Jun;5(6):391-3
pubmed: 19330011
J Mycol Med. 2017 Mar;27(1):1-19
pubmed: 27842800
Antimicrob Agents Chemother. 2014;58(2):1248-51
pubmed: 24323472
mBio. 2020 May 5;11(3):
pubmed: 32371596
FEMS Microbiol Rev. 2009 Sep;33(5):942-57
pubmed: 19519767
Antimicrob Agents Chemother. 2019 Aug 23;63(9):
pubmed: 31235622
Elife. 2015 Jan 19;4:e05048
pubmed: 25599565
Nature. 1976 Aug 19;262(5570):698-9
pubmed: 958440
Antimicrob Agents Chemother. 2012 Jul;56(7):3758-66
pubmed: 22508310
Am J Bot. 2011 Mar;98(3):426-38
pubmed: 21613136
Nature. 2018 Jun;558(7710):440-444
pubmed: 29899444
Dis Model Mech. 2019 Sep 12;12(9):
pubmed: 31413153
Crit Rev Microbiol. 2019 Feb;45(1):1-21
pubmed: 30628529
ISME J. 2008 Jan;2(1):27-36
pubmed: 18049456
Science. 2018 May 18;360(6390):739-742
pubmed: 29773744
Mar Drugs. 2018 Aug 29;16(9):
pubmed: 30158489
Cold Spring Harb Perspect Med. 2014 Nov 03;5(1):a019273
pubmed: 25367975
Expert Rev Anti Infect Ther. 2012 Jan;10(1):85-93
pubmed: 22149617
Mol Microbiol. 2000 Sep;37(5):989-94
pubmed: 10972818
J Antimicrob Chemother. 2016 Mar;71(3):572-5
pubmed: 26851273
Sci Rep. 2019 Feb 27;9(1):2900
pubmed: 30814593
Microbiome. 2017 Jul 19;5(1):82
pubmed: 28724401
Microorganisms. 2019 Nov 11;7(11):
pubmed: 31717918
Annu Rev Microbiol. 2009;63:599-623
pubmed: 19575567
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7839-43
pubmed: 7644502
Science. 2006 Jan 6;311(5757):81-3
pubmed: 16400148
J Antibiot (Tokyo). 1985 Dec;38(12):1699-713
pubmed: 3912360
J Biol Chem. 2020 Oct 16;295(42):14458-14472
pubmed: 32796038
J Med Microbiol. 2016 Apr;65(4):328-336
pubmed: 26847045
BMC Biol. 2010 Aug 26;8:109
pubmed: 20796277
Eukaryot Cell. 2011 Aug;10(8):1004-12
pubmed: 21642508
Cell Host Microbe. 2020 Jun 10;27(6):859-862
pubmed: 32526182
J Antibiot (Tokyo). 2017 Jan;70(1):45-51
pubmed: 27599768
Annu Rev Phytopathol. 2009;47:63-82
pubmed: 19400650
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12940-12945
pubmed: 27803316
Nat Commun. 2018 Feb 23;9(1):803
pubmed: 29476047
Proc Natl Acad Sci U S A. 2017 May 30;114(22):5601-5606
pubmed: 28461474
J Fungi (Basel). 2020 Oct 22;6(4):
pubmed: 33105672
Microbiol Mol Biol Rev. 2015 Nov 25;80(1):1-43
pubmed: 26609051