Rationale and design of the Baylor Infant Twin Study-A study assessing obesity-related risk factors from infancy.
design paper
epigenetics
infants
obesity
temperament
twin study
Journal
Obesity science & practice
ISSN: 2055-2238
Titre abrégé: Obes Sci Pract
Pays: United States
ID NLM: 101675151
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
14
09
2020
revised:
01
10
2020
accepted:
04
10
2020
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
9
3
2021
Statut:
epublish
Résumé
Early childhood (0-3 years) is a critical period for obesity prevention, when tendencies in eating behaviors and physical activity are established. Yet, little is understood about how the environment shapes children's genetic predisposition for these behaviors during this time. The Baylor Infant Twin Study (BITS) is a two phase study, initiated to study obesity risk factors from infancy. Data collection has been completed for Phase 1 in which three sub-studies pilot central measures for Phase 2. A novel infant temperament assessment, based on observations made by trained researchers was piloted in EpiTwin was a cross-sectional study of neonatal twins, while up to three study visits occurred for the other studies, at 4- (BOPP, BIO), 6- (BOPP), and 12- (BOPP, BIO) of age. Measurements for BOPP and BIO included temperament observations, feeding observations, and body composition assessments while EpiTwin focused on collecting samples of hair, urine, nails, and blood for quantifying methylation levels at 10 metastable epialleles. Additional data collected include demographic information, zygosity, chorionicity, and questionnaire-based measures of infant behaviors. Recruitment for all three studies was completed in early 2020. EpiTwin recruited 80 twin pairs (50% monochorionic), 31 twin pairs completed the BOPP protocol, and 68 singleton infants participated in BIO. The psychometric properties of the data from all three studies are being analyzed currently. The resulting findings will inform the development of the full BITS protocol, with the goal of completing assessments at 4-, 6-, 12-, and 14-month of age for 400 twin pairs.
Sections du résumé
BACKGROUND
BACKGROUND
Early childhood (0-3 years) is a critical period for obesity prevention, when tendencies in eating behaviors and physical activity are established. Yet, little is understood about how the environment shapes children's genetic predisposition for these behaviors during this time. The Baylor Infant Twin Study (BITS) is a two phase study, initiated to study obesity risk factors from infancy. Data collection has been completed for Phase 1 in which three sub-studies pilot central measures for Phase 2. A novel infant temperament assessment, based on observations made by trained researchers was piloted in
METHODS
METHODS
EpiTwin was a cross-sectional study of neonatal twins, while up to three study visits occurred for the other studies, at 4- (BOPP, BIO), 6- (BOPP), and 12- (BOPP, BIO) of age. Measurements for BOPP and BIO included temperament observations, feeding observations, and body composition assessments while EpiTwin focused on collecting samples of hair, urine, nails, and blood for quantifying methylation levels at 10 metastable epialleles. Additional data collected include demographic information, zygosity, chorionicity, and questionnaire-based measures of infant behaviors.
RESULTS
RESULTS
Recruitment for all three studies was completed in early 2020. EpiTwin recruited 80 twin pairs (50% monochorionic), 31 twin pairs completed the BOPP protocol, and 68 singleton infants participated in BIO.
CONCLUSIONS
CONCLUSIONS
The psychometric properties of the data from all three studies are being analyzed currently. The resulting findings will inform the development of the full BITS protocol, with the goal of completing assessments at 4-, 6-, 12-, and 14-month of age for 400 twin pairs.
Identifiants
pubmed: 33680493
doi: 10.1002/osp4.463
pii: OSP4463
pmc: PMC7909590
doi:
Types de publication
Journal Article
Langues
eng
Pagination
63-70Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Informations de copyright
© 2020 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
All authors declare they have no conflicts of interest.
Références
Obes Rev. 2014 Jan;15(1):9-18
pubmed: 23957249
Circulation. 2008 Jul 22;118(4):428-64
pubmed: 18591433
Trends Endocrinol Metab. 2004 May-Jun;15(4):183-7
pubmed: 15109618
Nat Commun. 2014 Apr 29;5:3746
pubmed: 24781383
PLoS Genet. 2010 Dec 23;6(12):e1001252
pubmed: 21203497
J Pediatr. 1998 Mar;132(3 Pt 1):523-6
pubmed: 9544914
Acta Paediatr. 2006 Aug;95(8):904-8
pubmed: 16882560
J Pediatr. 1987 May;110(5):799-804
pubmed: 3572635
J Dev Behav Pediatr. 2012 Nov-Dec;33(9):732-45
pubmed: 23095495
Int J Obes Relat Metab Disord. 2004 Apr;28(4):503-13
pubmed: 14758342
J Law Med Ethics. 2007 Spring;35(1):22-34
pubmed: 17341215
Behav Genet. 2016 Nov;46(6):763-771
pubmed: 27406596
JAMA Pediatr. 2015 May;169(5):484-90
pubmed: 25775180
Eur J Clin Nutr. 2010 Nov;64(11):1316-22
pubmed: 20717131
J Pediatr. 1990 May;116(5):805-9
pubmed: 2329430
Dysphagia. 2011 Sep;26(3):277-86
pubmed: 20853119
New Dir Child Dev. 1992 Spring;(55):7-23
pubmed: 1608516
Appetite. 2016 Feb 1;97:72-8
pubmed: 26612089
Nat Biotechnol. 2010 Oct;28(10):1097-105
pubmed: 20852635
Am J Clin Nutr. 1999 Feb;69(2):179-97
pubmed: 9989679
Genome Biol. 2018 Jan 9;19(1):2
pubmed: 29310692
J Pers Assess. 2014;96(4):445-58
pubmed: 24206185
Appetite. 2011 Oct;57(2):388-96
pubmed: 21672566
Front Psychol. 2017 May 24;8:846
pubmed: 28596748
Arch Pediatr Adolesc Med. 2011 Nov;165(11):993-8
pubmed: 22065180
Hum Mol Genet. 2002 May 15;11(11):1317-25
pubmed: 12019213
Curr Nutr Rep. 2018 Mar;7(1):1-9
pubmed: 29892784
JAMA. 2012 Feb 1;307(5):483-90
pubmed: 22253364
Paediatr Perinat Epidemiol. 2012 Jan;26(1):19-26
pubmed: 22150704