IL-10 and TGF-β Induced Arginase Expression Contributes to Deficient Nitric Oxide Response in Human Visceral Leishmaniasis.
IL-10
TGF-beta
arginase
nitric oxide
visceral leishmaniasis
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
10
2020
accepted:
31
12
2020
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Nitric oxide (NO) is an anti-microbial effector of the innate immune system which plays major role in non-specific killing of various pathogens including protozoan parasites. However, due to subversion of the host's immune processes by pathogens, suboptimal production of NO is frequently found in many infection models. Previous studies have shown suppressed NO production during
Identifiants
pubmed: 33680983
doi: 10.3389/fcimb.2020.614165
pmc: PMC7930829
doi:
Substances chimiques
Cytokines
0
IL10 protein, human
0
Transforming Growth Factor beta
0
Interleukin-10
130068-27-8
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type II
EC 1.14.13.39
Arginase
EC 3.5.3.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
614165Subventions
Organisme : NIAID NIH HHS
ID : U19 AI074321
Pays : United States
Informations de copyright
Copyright © 2021 Kupani, Sharma, Pandey, Kumar, Sundar and Mehrotra.
Déclaration de conflit d'intérêts
RK was employed by Thermo Fisher Scientific. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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