CD5 levels define functionally heterogeneous populations of naïve human CD4
Animals
Autoantigens
/ metabolism
Biomarkers
/ metabolism
CD4-Positive T-Lymphocytes
/ immunology
CD5 Antigens
/ metabolism
Cells, Cultured
Clonal Selection, Antigen-Mediated
Humans
Immunologic Memory
Immunological Synapses
Immunotherapy, Adoptive
/ methods
Mice
Mice, Inbred C57BL
Protein Binding
Receptors, Antigen, T-Cell
/ metabolism
Signal Transduction
T-Lymphocyte Subsets
/ immunology
CD4+ T cells
CD5
Cytokines
Human T cells
Thymus
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
27
12
2020
received:
02
06
2020
accepted:
04
03
2021
pubmed:
9
3
2021
medline:
25
9
2021
entrez:
8
3
2021
Statut:
ppublish
Résumé
Studies in murine models show that subthreshold TCR interactions with self-peptide are required for thymic development and peripheral survival of naïve T cells. Recently, differences in the strength of tonic TCR interactions with self-peptide, as read-out by cell surface levels of CD5, were associated with distinct effector potentials among sorted populations of T cells in mice. However, whether CD5 can also be used to parse functional heterogeneity among human T cells is less clear. Our study demonstrates that CD5 levels correlate with TCR signal strength in human naïve CD4
Identifiants
pubmed: 33682083
doi: 10.1002/eji.202048788
pmc: PMC8251777
doi:
Substances chimiques
Autoantigens
0
Biomarkers
0
CD5 Antigens
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1365-1376Subventions
Organisme : CIHR
ID : MSH-141967
Pays : Canada
Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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