RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches.
Animals
DNA-Binding Proteins
/ genetics
Diagnosis, Differential
Disease Management
Disease Models, Animal
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Therapy
Genotype
Homeodomain Proteins
/ genetics
Humans
Mutation
Nuclear Proteins
/ genetics
Phenotype
Severe Combined Immunodeficiency
/ diagnosis
V(D)J Recombination
/ genetics
Genotype-phenotype correlation
Immune tolerance
RAG
VDJ recombination
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
13
01
2021
received:
13
01
2021
accepted:
03
03
2021
pubmed:
9
3
2021
medline:
28
9
2021
entrez:
8
3
2021
Statut:
ppublish
Résumé
The RAG1 and RAG2 proteins initiate the process of V(D)J recombination and therefore play an essential role in adaptive immunity. While null mutations in the RAG genes cause severe combined immune deficiency with lack of T and B cells (T
Identifiants
pubmed: 33682138
doi: 10.1002/eji.202048880
pmc: PMC8325549
mid: NIHMS1727102
doi:
Substances chimiques
DNA-Binding Proteins
0
Homeodomain Proteins
0
Nuclear Proteins
0
RAG2 protein, human
0
RAG-1 protein
128559-51-3
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1028-1038Subventions
Organisme : Intramural NIH HHS
ID : ZIA AI001222
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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