Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study.
Journal
Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064
Informations de publication
Date de publication:
17 06 2020
17 06 2020
Historique:
received:
29
05
2020
accepted:
17
06
2020
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
4
6
2021
Statut:
epublish
Résumé
Background and aim Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL). As histamine is the pivotal pathogenic mediator in SAR, antihistamines are the first-line option in the treatment. Cetirizine is a well-known effective antihistamine. This real-life pilot study aimed to investigate the effectiveness of a 4-week continuous cetirizine treatment in a group of Italian children with SAR. Methods Total symptom score (TSS) and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline and the end of the treatment. Results Cetirizine significantly improved QoL (in all domains) and symptom severity (p<0.001 for both). Conclusions The present preliminary study showed that a 4-week cetirizine treatment was able to improve QoL significantly. Cetirizine treatment also significantly reduced symptom severity in Italian children with SAR and was safe.
Identifiants
pubmed: 33682837
doi: 10.23750/abm.v92i1.9948
pmc: PMC7975941
doi:
Substances chimiques
Cetirizine
YO7261ME24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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