Preparation, characterization, and cytotoxicity evaluation of self-assembled nanoparticles of diosgenin-cytarabine conjugate.

Antimetabolites, Antineoplastic / administration & dosage Cell Line, Tumor Cell Survival / drug effects Cytarabine / administration & dosage Diosgenin / administration & dosage Drug Carriers Drug Screening Assays, Antitumor Humans Nanoparticles / chemistry
Anti-tumor activity Cytarabine Diosgenin Diosgenin-cytarabine conjugate Self-assembled nanoparticle

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483

Informations de publication

Date de publication:
May 2021
Historique:
received: 15 02 2021
revised: 26 02 2021
accepted: 01 03 2021
pubmed: 9 3 2021
medline: 15 9 2021
entrez: 8 3 2021
Statut: ppublish

Résumé

Diosgenin (DG) isolated from yam roots revealed various bioactivities and applications as drug carrier. In the present study, a conjugate of DG with cytarabine (Ara-C) was used to prepare the self-assembled nanoparticles (NPs) of DG-Ara-C by a nanoprecipitation method. Dynamic light scattering (DLS) as well as transmission electron microscopy (TEM) were employed to analyze the size and the morphology of NPs, respectively. The stability and absorption of DG-Ara-C NPs were measured. Additionally, the cytotoxicity of the NPs was determined via MTT assay. The results indicated that the average particle size of DG-Ara-C NPs was around 190 nm with a narrow size distribution (PDI = 0.1). TEM showed that DG-Ara-C NPs had a spherical morphology. Compared to free DG or Ara-C, the self-assembled DG-Ara-C NPs exhibited a better anti-tumor activity against solid tumor cells as well as leukemia cells. In conclusion, DG possesses dual role in the self-assembled NPs of DG-Ara-C conjugate, being as a promising anticancer drug and drug carrier.

Identifiants

DOI: 10.1016/j.fct.2021.112101 PMID: 33684518
pubmed: 33684518
pii: S0278-6915(21)00134-4
doi: 10.1016/j.fct.2021.112101
pii:
doi:

Substances chimiques

Antimetabolites, Antineoplastic 0
Drug Carriers 0
Cytarabine 04079A1RDZ
Diosgenin K49P2K8WLX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112101

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Ai-Mei Liao (AM)

College of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China; College of Pharmacy, Chonnam National University, Gwangju, 61186, Republic of Korea.

Ying Zhang (Y)

Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.

Yinchen Hou (Y)

College of Food and Biological Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou, 450046, China.

Ji-Hong Huang (JH)

College of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China; Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, PR China.

Ming Hui (M)

College of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Kyung-Ku Lee (KK)

Testing and Evaluation Center for Dental Devices, Chonnam National University Dental Hospital, Gwangju, 61186, Republic of Korea.

Kwang Youl Lee (KY)

College of Pharmacy, Chonnam National University, Gwangju, 61186, Republic of Korea. Electronic address: kwanglee@chonnam.ac.kr.

ChangJu Chun (C)

College of Pharmacy, Chonnam National University, Gwangju, 61186, Republic of Korea; Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Zhengzhou, 450001, PR China. Electronic address: cchun1130@jnu.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Antimétabolites › Antimétabolites antinéoplasiques › Preparation, characterization, and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Preparation, characterization, and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Preparation, characterization, and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Cytarabine › Preparation, characterization, and...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholestanes › Spirostanes › Diosgénine › Preparation, characterization, and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Preparation, characterization, and...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Preparation, characterization, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Preparation, characterization, and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Preparation, characterization, and...