Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs.
Abruzzo
Coronavirus
Italy
SARS-CoV-2
VOC 202012/01
lineage B.1.1.7
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
25
02
2021
revised:
27
02
2021
accepted:
02
03
2021
pubmed:
9
3
2021
medline:
1
6
2021
entrez:
8
3
2021
Statut:
ppublish
Résumé
Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/
01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region
(Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of February
2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to
February 2021 to verify any difference on the viral load and persistence between people infected by
lineage B.1.1.7 and others. Statistically significant lower values of CT associated with the detection of the
N protein encoding gene (CT N) were observed in persons with lineage B.1.1.7 infection (median
CT N = 15.8)in comparison to those infected by other lineages (median CT N = 16.9). A significantly longer
duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with
lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).
Identifiants
pubmed: 33684558
pii: S1201-9712(21)00210-1
doi: 10.1016/j.ijid.2021.03.005
pmc: PMC7934691
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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