Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome.
Anthropometry
/ methods
Body Mass Index
Caloric Restriction
/ methods
Cholesterol Ester Transfer Proteins
/ blood
Cholesterol, HDL
/ blood
Cholesterol, LDL
/ blood
Cytokines
/ blood
Diet, Reducing
/ methods
Female
Humans
Lipid Metabolism
/ physiology
Male
Metabolic Syndrome
/ blood
Middle Aged
Treatment Outcome
Triglycerides
/ blood
Weight Loss
/ immunology
Caloric restriction
Cholesteryl ester transfer protein
Lipids
Metabolic syndrome
Pro-inflammatory cytokines
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
24
12
2020
accepted:
01
03
2021
pubmed:
10
3
2021
medline:
8
2
2022
entrez:
9
3
2021
Statut:
ppublish
Résumé
Weight loss in patients with metabolic syndrome has positive effects on cardiovascular and type 2 diabetes risks, but its effects on peripheral cytokines and lipid profiles in patients are still unclear. To determine the effects of diet-induced weight loss on metabolic parameters, lipids and cytokine profiles. Eighteen adult males with metabolic syndrome (defined according to IDF 2009) and Body Mass Index (BMI) between 25 and 35 kg/m After weight loss, a significant improvement in BMI, waist circumference, insulin, fasting blood glucose and HOMA-IR (homeostasis model assessment of insulin resistance) was observed. The analysis of LDL (low-density lipoprotein cholesterol) and HDL (high-density lipoprotein cholesterol) lipoproteins showed a change in their composition with a massive transfer of triacylglycerols from HDL to LDL. This was associated with a significant reduction in peripheral pro-inflammatory cytokines such as IL-6, TNF-α, IL-8 and MIP-1β, leading to an overall decreased inflammatory score. An interesting positive correlation was also observed among peripheral cytokines levels after diet and peripheral levels of CETP (cholesteryl ester transfer protein), an enzyme with a key role in lipid change. Weight loss through caloric restriction is associated with an improvement in peripheral lipid and cytokine profiles that may play a major role in improving cardiovascular risk.
Sections du résumé
BACKGROUND
BACKGROUND
Weight loss in patients with metabolic syndrome has positive effects on cardiovascular and type 2 diabetes risks, but its effects on peripheral cytokines and lipid profiles in patients are still unclear.
AIM
OBJECTIVE
To determine the effects of diet-induced weight loss on metabolic parameters, lipids and cytokine profiles.
METHODS
METHODS
Eighteen adult males with metabolic syndrome (defined according to IDF 2009) and Body Mass Index (BMI) between 25 and 35 kg/m
RESULTS
RESULTS
After weight loss, a significant improvement in BMI, waist circumference, insulin, fasting blood glucose and HOMA-IR (homeostasis model assessment of insulin resistance) was observed. The analysis of LDL (low-density lipoprotein cholesterol) and HDL (high-density lipoprotein cholesterol) lipoproteins showed a change in their composition with a massive transfer of triacylglycerols from HDL to LDL. This was associated with a significant reduction in peripheral pro-inflammatory cytokines such as IL-6, TNF-α, IL-8 and MIP-1β, leading to an overall decreased inflammatory score. An interesting positive correlation was also observed among peripheral cytokines levels after diet and peripheral levels of CETP (cholesteryl ester transfer protein), an enzyme with a key role in lipid change.
CONCLUSION
CONCLUSIONS
Weight loss through caloric restriction is associated with an improvement in peripheral lipid and cytokine profiles that may play a major role in improving cardiovascular risk.
Identifiants
pubmed: 33686615
doi: 10.1007/s40618-021-01547-y
pii: 10.1007/s40618-021-01547-y
pmc: PMC8502121
doi:
Substances chimiques
Cholesterol Ester Transfer Proteins
0
Cholesterol, HDL
0
Cholesterol, LDL
0
Cytokines
0
Triglycerides
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2407-2415Subventions
Organisme : Università degli Studi di Milano
ID : Linea2 2019
Organisme : European Foundation for the Study of Diabetes
ID : EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research 2019
Organisme : Ministero della Salute
ID : RF-2016-02362512
Informations de copyright
© 2021. The Author(s).
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