Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney.
aging
computational biology
kidney
mRNA
mouse
protein
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 03 2021
09 03 2021
Historique:
received:
01
09
2020
accepted:
06
03
2021
pubmed:
10
3
2021
medline:
29
1
2022
entrez:
9
3
2021
Statut:
epublish
Résumé
Little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand these changes, we measured mRNA and protein levels in genetically diverse mice at different ages. We observed distinctive change in mRNA and protein levels as a function of age. Changes in both mRNA and protein are associated with increased immune infiltration and decreases in mitochondrial function. Proteins show a greater extent of change and reveal changes in a wide array of biological processes including unique, organ-specific features of aging in kidney. Most importantly, we observed functionally important age-related changes in protein that occur in the absence of corresponding changes in mRNA. Our findings suggest that mRNA profiling alone provides an incomplete picture of molecular aging in the kidney and that examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.
Identifiants
pubmed: 33687326
doi: 10.7554/eLife.62585
pii: 62585
pmc: PMC8096428
doi:
pii:
Substances chimiques
Proteome
0
Banques de données
GEO
['GSE121330']
figshare
['10.6084/m9.figshare.12894146']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Informations de copyright
© 2021, Takemon et al.
Déclaration de conflit d'intérêts
YT, JC, IG, DS, OD, SG, GC, RK No competing interests declared
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