Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy.
Dosimetry
Hepatocellular carcinoma
Radioembolization
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
09 Mar 2021
09 Mar 2021
Historique:
received:
28
10
2020
accepted:
23
02
2021
entrez:
9
3
2021
pubmed:
10
3
2021
medline:
10
3
2021
Statut:
epublish
Résumé
The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosimetry, for patients with advanced HCC treated with SIRT. Forty-eight patients who underwent SIRT between 2012 and 2020 were retrospectively included in this study. Target volumes were delineated using two methods: MRI-based contours manually drawn by a radiologist and then registered on SPECT/CT and PET/CT via deformable registration (Pre-C No significant differences were found for Dm and TNR between pre- and post-treatment. TNR evaluated with radiologic contours (Pre-C In advanced HCC treated with SIRT, Dm and TNR determined with radiologic contours were predictive of tumor control and OS. This study shows that a rigorous clinical workflow (radiologic contours + registration on scintigraphic images) is feasible and should be prospectively considered for improving therapeutic strategy.
Identifiants
pubmed: 33687596
doi: 10.1186/s13550-021-00766-x
pii: 10.1186/s13550-021-00766-x
pmc: PMC7943673
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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