Antibiotic Susceptibility Patterns of Bacterial Isolates from Routine Clinical Specimens from Referral Hospitals in Tanzania: A Prospective Hospital-Based Observational Study.
AMR
MRSA
antibiotic susceptibility testing
antibiotics
antimicrobial resistance
bacterial isolates
methicillin-resistant Staphylococcus aureus
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
12
2020
accepted:
22
01
2021
entrez:
10
3
2021
pubmed:
11
3
2021
medline:
11
3
2021
Statut:
epublish
Résumé
Antimicrobial resistance is one of the biggest threats of modern public health. Although sub-Saharan Africa is highly burdened with infectious diseases, current data on antimicrobial resistance are sparse. A prospective study was conducted between October 2018 and September 2019 to assess the antibiotic susceptibility patterns of clinical bacterial isolates obtained from four referral hospitals in Tanzania. We used standard media and Kirby-Bauer disc diffusion methods as per Clinical and Laboratory Standards Institute (CLSI) standards. We processed a total of 2620 specimens of which 388 (14.8%) were culture-positive from patients with a median (IQR) age of 28 (12-44) years. Of the positive cultures, 52.3% (203) were from females. Most collected specimens were ear pus 28.6% (111), urine 24.0% (93), wound pus 20.6% (80), stool 14.9% (58), and blood 8.3% (32). Predominant isolates were Antibiotic resistance to commonly prescribed antibiotics was alarmingly high. Our findings emphasize the need for comprehensive national control programs to combat antibiotic resistance.
Identifiants
pubmed: 33688222
doi: 10.2147/IDR.S294575
pii: 294575
pmc: PMC7937390
doi:
Types de publication
Journal Article
Langues
eng
Pagination
869-878Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2021 Mnyambwa et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest for this work.
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