Intravitreal Therapy for Diabetic Macular Edema: An Update.
Journal
Journal of ophthalmology
ISSN: 2090-004X
Titre abrégé: J Ophthalmol
Pays: United States
ID NLM: 101524199
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
11
2020
revised:
11
02
2021
accepted:
16
02
2021
entrez:
10
3
2021
pubmed:
11
3
2021
medline:
11
3
2021
Statut:
epublish
Résumé
Diabetic macular edema (DME) represents a prevalent and disabling eye condition. Despite that DME represents a sight-threatening condition, it is also among the most accessible to treatment. Many different treatment options including photocoagulation, intravitreal medical treatment (either vascular endothelial growth factor inhibitors or corticosteroids therapies), and surgical removal are currently available. Although laser has been considered as the gold standard for many years, over the past several years vascular endothelial growth factor inhibitors (anti-VEGFs) have become first-line therapy. However, many patients do not adequately respond to them. With the development of sustained-release corticosteroid devices, steroids have gained a presence in the management of the DME. We review and update the role of anti-VEGF and intravitreal sustained-release corticosteroid management of DME. According to the currently available scientific evidence, the choice of one anti-VEGF over another critically depends on the baseline best-corrected visual acuity (BCVA). While aflibercept may be the drug of choice in low baseline BCVA, the three anti-VEGFs (bevacizumab, ranibizumab, and aflibercept) provided similar functional outcomes when the baseline BCVA was higher. DEX implants are a valuable option for treating DME, although they are usually seen as a second choice, particularly in those eyes that have an insufficient response to anti-VEGF. The new evidence suggested that, in eyes that did not adequately respond to anti-VEGF, switching to a DEX implant at the time to 3 monthly anti-VEGF injections provided better functional outcomes.
Identifiants
pubmed: 33688431
doi: 10.1155/2021/6654168
pmc: PMC7925023
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
6654168Informations de copyright
Copyright © 2021 Claudio Furino et al.
Déclaration de conflit d'intérêts
Dr. Claudio Furino has received a grant from Allergan during the conduct of the study. Dr. Francesco Boscia, Dr. Michele Reibaldi, and Dr. Giovanni Alessio declare that they have no conflicts of interest.
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