Identification and Development of Therapeutics for COVID-19.


Journal

ArXiv
ISSN: 2331-8422
Titre abrégé: ArXiv
Pays: United States
ID NLM: 101759493

Informations de publication

Date de publication:
03 Mar 2021
Historique:
pubmed: 11 3 2021
medline: 11 3 2021
entrez: 10 3 2021
Statut: epublish

Résumé

After emerging in China in late 2019, the novel coronavirus SARS-CoV-2 spread worldwide and as of mid-2021 remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2:

Identifiants

pubmed: 33688554
pii: 2103.02723
pmc: PMC7941644
pii:

Types de publication

Preprint

Langues

eng

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Competing Interests AuthorCompeting InterestsLast ReviewedHalie M. RandoNone2021-01-20Nils WellhausenNone2020-11-03Soumita GhoshNone2020-11-09Alexandra J. LeeNone2020-11-09Anna Ada DattoliNone2020-03-26Fengling HuNone2020-04-08James Brian ByrdFunded by FastGrants to conduct a COVID-19-related clinical trial2020-11-12Diane N. RafizadehNone2020-11-11Ronan LordanNone2020-11-03Yanjun QiNone2020-07-09Yuchen SunNone2020-11-11Christian BruefferEmployee and shareholder of SAGA Diagnostics AB.2020-11-11Jeffrey M. FieldNone2020-11-12Marouen Ben GuebilaNone2021-08-02Nafisa M. JadavjiNone2020-11-11Ashwin N. SkellyNone2020-11-11Bharath RamsundarNone2020-11-11Jinhui WangNone2021-01-21Rishi Raj GoelNone2021-01-20YoSon ParkNow employed by Pfizer (subsequent to contributions to this project)2020-01-22COVID-19 Review ConsortiumNone2021-01-16Simina M. BocaCurrently an employee at AstraZeneca, Gaithersburg, MD, USA, may own stock or stock options. Work initially conducted at Georgetown University Medical Center with writing, reviewing, and editing continued while working at AstraZeneca.2021-07-01Anthony GitterFiled a patent application with the Wisconsin Alumni Research Foundation related to classifying activated T cells2020-11-10Casey S. GreeneNone2021-01-20

Références

Science. 2020 Aug 21;369(6506):1010-1014
pubmed: 32540901
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Open Forum Infect Dis. 2021 Feb 01;8(2):ofab050
pubmed: 33623808
Virol J. 2011 Apr 12;8:163
pubmed: 21481279
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
N Engl J Med. 2021 Feb 11;384(6):497-511
pubmed: 33264556
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Br J Pharmacol. 2018 Jan;175(2):181-191
pubmed: 28685814
Blood. 2014 Jul 10;124(2):188-95
pubmed: 24876563
Int J Biol Sci. 2012;8(9):1237-47
pubmed: 23136552
Am J Clin Pathol. 2020 Mar 9;153(4):420-421
pubmed: 32053148
JAMA. 2020 Dec 8;324(22):2292-2300
pubmed: 33180097
Patterns (N Y). 2020 Sep 11;1(6):100090
pubmed: 32838343
JAMA. 2020 Sep 15;324(11):1048-1057
pubmed: 32821939
J Antimicrob Chemother. 2020 Jul 1;75(7):1667-1670
pubmed: 32196083
Rheumatology (Oxford). 2012 May;51(5):852-7
pubmed: 21865281
Cell Rep. 2021 Apr 6;35(1):108959
pubmed: 33811811
Antimicrob Agents Chemother. 2005 Mar;49(3):981-6
pubmed: 15728892
J Med Virol. 2016 Dec;88(12):2170-2178
pubmed: 27183377
Science. 2021 Jul 30;373(6554):488-489
pubmed: 34326222
Protein Cell. 2013 Apr;4(4):248-50
pubmed: 23549610
Am J Trop Med Hyg. 2020 Jun;102(6):1156-1157
pubmed: 32314704
PLoS One. 2020 Jul 9;15(7):e0235458
pubmed: 32645044
Vaccine. 2006 Jun 29;24(26):5498-508
pubmed: 16725238
Crit Care. 2011 Mar 15;15(2):R96
pubmed: 21406101
Clin Pharmacol Ther. 2013 Apr;93(4):299-301
pubmed: 23511784
Med Microbiol Immunol. 2006 Dec;195(4):173-83
pubmed: 16741736
Chest. 2021 Jan;159(1):85-92
pubmed: 33065103
PLoS Negl Trop Dis. 2012;6(11):e1883
pubmed: 23133688
QJM. 2022 Jan 5;114(11):780-788
pubmed: 33599247
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219
pubmed: 32391667
Virus Res. 2014 Dec 19;194:124-37
pubmed: 25093995
J Biomed Sci. 2020 Jan 2;27(1):1
pubmed: 31894001
Nat Biotechnol. 2021 Jul;39(7):783-785
pubmed: 34158667
J Infect Dis. 2010 Mar 15;201(6):946-55
pubmed: 20144042
Am J Ther. 2021 Jun 21;28(4):e434-e460
pubmed: 34145166
N Engl J Med. 2003 May 15;348(20):1947-8
pubmed: 12748313
Int J Antimicrob Agents. 2020 Sep;56(3):106114
pubmed: 32712334
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Science. 2021 Jul 30;373(6554):541-547
pubmed: 34326236
BMJ. 2020 Sep 4;370:m3379
pubmed: 32887691
Sci Rep. 2016 Mar 07;6:22677
pubmed: 26948040
Methods Mol Biol. 2015;1282:v
pubmed: 25870870
Cardiovasc Res. 2020 Aug 1;116(10):1688-1699
pubmed: 32293003
Cell Res. 2020 Mar;30(3):269-271
pubmed: 32020029
Nat Commun. 2020 May 4;11(1):2251
pubmed: 32366817
Alzheimers Dement (N Y). 2017 Nov 11;3(4):651-657
pubmed: 29255791
Neuroendocrinology. 2000 Aug;72(2):114-25
pubmed: 10971146
Lancet. 2021 May 1;397(10285):1603-1605
pubmed: 33865497
Europace. 2017 Aug 01;19(8):1280-1287
pubmed: 27738071
Clin Microbiol Infect. 2004 Dec;10(12):1062-6
pubmed: 15606632
N Engl J Med. 2021 Jan 21;384(3):229-237
pubmed: 33113295
Lancet. 2020 Feb 29;395(10225):683-684
pubmed: 32122468
Sci Transl Med. 2017 Jun 28;9(396):
pubmed: 28659436
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731
pubmed: 32226290
Clin Infect Dis. 2020 Jul 28;71(15):732-739
pubmed: 32150618
BMJ. 2008 May 3;336(7651):1006-9
pubmed: 18434379
Case Rep Cardiol. 2016;2016:4626279
pubmed: 27478650
Science. 2009 Apr 10;324(5924):246-51
pubmed: 19251591
JAMA Netw Open. 2021 Apr 1;4(4):e216468
pubmed: 33885775
PLoS Med. 2006 Sep;3(9):e343
pubmed: 16968120
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102186
pubmed: 34237554
Immunity. 2008 Jan;28(1):52-63
pubmed: 18191596
Immunity. 2021 Jun 8;54(6):1276-1289.e6
pubmed: 33836142
Antiviral Res. 2017 Jul;143:30-37
pubmed: 28389142
Engineering (Beijing). 2020 Oct;6(10):1192-1198
pubmed: 32346491
Expert Rev Precis Med Drug Dev. 2019;4(3):189-200
pubmed: 31286058
Antimicrob Agents Chemother. 1979 Mar;15(3):361-7
pubmed: 464561
Biosci Trends. 2020 Mar 16;14(1):72-73
pubmed: 32074550
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
N Engl J Med. 2012 Nov 8;367(19):1814-20
pubmed: 23075143
Cold Spring Harb Perspect Biol. 2014 Sep 04;6(10):a016295
pubmed: 25190079
Lancet. 2020 Feb 15;395(10223):e30-e31
pubmed: 32032529
Nat Commun. 2020 Jul 14;11(1):3518
pubmed: 32665542
Hum Vaccin Immunother. 2017 Sep 2;13(9):2138-2149
pubmed: 28605249
Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(2):13-28
pubmed: 21321478
Chem Soc Rev. 2021 Aug 21;50(16):9121-9151
pubmed: 34212944
Antimicrob Agents Chemother. 2009 Jan;53(1):202-9
pubmed: 18955536
Antimicrob Agents Chemother. 2011 Feb;55(2):782-7
pubmed: 21115797
N Engl J Med. 2020 Aug 6;383(6):517-525
pubmed: 32492293
Cell. 2003 Dec 12;115(6):652-3
pubmed: 14675530
Science. 2021 Feb 19;371(6531):823-829
pubmed: 33495307
JAMA. 2021 Mar 23;325(12):1185-1195
pubmed: 33635310
Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80
pubmed: 22809499
Nat Rev Immunol. 2018 May;18(5):297-308
pubmed: 29379211
Nat Rev Drug Discov. 2011 Jun 24;10(7):507-19
pubmed: 21701501
J Med Virol. 2020 Sep;92(9):1475-1483
pubmed: 32356910
Curr Opin Immunol. 2013 Oct;25(5):588-92
pubmed: 24011665
Clin Pharmacol Ther. 2020 Oct;108(4):762-765
pubmed: 32378737
J Infect Dis. 2016 May 15;213(10):1557-61
pubmed: 26941283
J Med Internet Res. 2021 Mar 12;23(3):e26718
pubmed: 33684053
J Infect Chemother. 2004 Feb;10(1):1-7
pubmed: 14991510
Ther Adv Chronic Dis. 2013 Jul;4(4):167-85
pubmed: 23819020
Ann Rheum Dis. 2019 Apr;78(4):456-464
pubmed: 30679153
J Infect Dis. 2004 Sep 15;190(6):1119-26
pubmed: 15319862
Curr Neuropharmacol. 2005 Oct;3(4):267-80
pubmed: 18369400
Nat Rev Rheumatol. 2020 Mar;16(3):155-166
pubmed: 32034323
Expert Opin Biol Ther. 2009 Mar;9(3):355-68
pubmed: 19216624
Eur Respir J. 2008 Aug;32(2):259-64
pubmed: 18669784
Cytokine. 2015 Apr;72(2):210-9
pubmed: 25703786
N Engl J Med. 2021 Mar 18;384(11):1015-1027
pubmed: 33523609
N Engl J Med. 2020 Dec 3;383(23):2255-2273
pubmed: 33264547
Antimicrob Agents Chemother. 2007 Mar;51(3):845-51
pubmed: 17194832
Lancet Respir Med. 2021 Mar;9(3):275-284
pubmed: 33422263
N Engl J Med. 2020 Nov 5;383(19):1827-1837
pubmed: 32459919
JAMA. 2021 Feb 16;325(7):632-644
pubmed: 33475701
Chem Commun (Camb). 2018 Aug 21;54(68):9506-9509
pubmed: 30091742
Nat Rev Drug Discov. 2019 Jan;18(1):41-58
pubmed: 30310233
N Engl J Med. 2019 Apr 25;380(17):1589-1591
pubmed: 30865819
N Engl J Med. 2020 Jun 18;382(25):e102
pubmed: 32356626
Eur Arch Psychiatry Clin Neurosci. 2021 Mar;271(2):249-258
pubmed: 33403480
Lancet Rheumatol. 2020 Aug;2(8):e474-e484
pubmed: 32835257
Antiviral Res. 2018 Jun;154:66-86
pubmed: 29649496
N Engl J Med. 2020 Mar 5;382(10):929-936
pubmed: 32004427
Nat Rev Microbiol. 2004 Dec;2(12):984-9
pubmed: 15550944
Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4
pubmed: 33535027
Eur Heart J. 2020 Dec 7;41(46):4387-4388
pubmed: 33306101
Rheumatology (Oxford). 2019 Aug 1;58(8):1505-1507
pubmed: 30945743
EClinicalMedicine. 2021 Feb;32:100720
pubmed: 33495752
Dermatol Ther. 2007 Jul-Aug;20(4):160-74
pubmed: 17970883
Assay Drug Dev Technol. 2019 Nov/Dec;17(8):352-363
pubmed: 31769998
Open Forum Infect Dis. 2021 Jul 06;8(11):ofab358
pubmed: 34796244
Nat Rev Drug Discov. 2014 Aug;13(8):588-602
pubmed: 25033736
Crit Care. 2020 Aug 21;24(1):516
pubmed: 32825837
Med. 2020 Dec 18;1(1):114-127.e3
pubmed: 32838355
Ther Adv Musculoskelet Dis. 2018 Oct 07;10(10):195-199
pubmed: 30327685
Chest. 2007 Mar;131(3):913-920
pubmed: 17356114
Sci Transl Med. 2020 Apr 29;12(541):
pubmed: 32253226
Curr Drug Metab. 2006 Jan;7(1):15-21
pubmed: 16454690
Antimicrob Agents Chemother. 2007 Sep;51(9):3168-76
pubmed: 17606691
Lancet Digit Health. 2020 Dec;2(12):e667-e676
pubmed: 32984792
PLoS One. 2012;7(10):e47926
pubmed: 23112872
Autoimmun Rev. 2014 Jun;13(6):685-96
pubmed: 24468415
Cochrane Database Syst Rev. 2017 Dec 13;12:CD007720
pubmed: 29236286
Thorax. 2004 Aug;59(8):643-5
pubmed: 15282381
Front Pharmacol. 2021 Apr 20;12:652688
pubmed: 33959018
mBio. 2018 Mar 6;9(2):
pubmed: 29511076
Biol Chem. 2019 Dec 18;401(1):31-46
pubmed: 31408430
Sci Transl Med. 2019 Feb 6;11(478):
pubmed: 30728287
N Engl J Med. 2021 Mar 4;384(9):795-807
pubmed: 33306283
N Engl J Med. 2020 Nov 19;383(21):2030-2040
pubmed: 33031652
Heart Rhythm. 2008 Aug;5(8):1213-5
pubmed: 18675237
Mol Biol Rep. 2014 Aug;41(8):4865-79
pubmed: 24867080
JAMA. 2020 Feb 25;323(8):725-733
pubmed: 32065831
Hypertension. 2004 Dec;44(6):903-6
pubmed: 15492138
Nat Med. 2004 Aug;10(8):871-5
pubmed: 15247913
Proc Assoc Am Physicians. 1996 Sep;108(5):374-81
pubmed: 8902882
Nat Rev Drug Discov. 2021 Apr;20(4):254-255
pubmed: 33633370
J Antibiot (Tokyo). 2020 Sep;73(9):593-602
pubmed: 32533071
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
Lancet Infect Dis. 2020 Apr;20(4):398-400
pubmed: 32113510
Drug Discov Today. 2019 Oct;24(10):2076-2085
pubmed: 31238113
J Biol Chem. 2020 Apr 10;295(15):4773-4779
pubmed: 32094225
Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007720
pubmed: 21412908
Antiviral Res. 2015 Apr;116:76-84
pubmed: 25666761
Lung. 2007 Sep-Oct;185(5):249-255
pubmed: 17710485
J Virus Erad. 2020 Apr 30;6(2):45-51
pubmed: 32405421
Lancet Infect Dis. 2020 Apr;20(4):400-402
pubmed: 32113509
JAMA. 1960 Oct 15;174:831-4
pubmed: 13694317
Eur J Pharm Sci. 2021 Feb 1;157:105631
pubmed: 33115675
Toxicol Rep. 2021;8:505-510
pubmed: 33723507
Med Mal Infect. 2020 Jun;50(4):384
pubmed: 32240719
J Clin Virol. 2004 Jul;30(3):211-3
pubmed: 15135736
J Biol Regul Homeost Agents. 2020 Jun 04;34(3):1241-1243
pubmed: 32551464
Biosaf Health. 2021 Apr;3(2):87-91
pubmed: 33585808
Am J Trop Med Hyg. 2021 Jan;104(1):35-38
pubmed: 33236703
Int J Infect Dis. 2021 Feb;103:214-216
pubmed: 33278625
Antiviral Res. 2020 Jun;178:104787
pubmed: 32251768
Lancet Respir Med. 2020 Mar;8(3):267-276
pubmed: 32043986
Lancet Respir Med. 2020 Dec;8(12):1170-1172
pubmed: 33129421
Arch Virol. 2021 Mar;166(3):949-954
pubmed: 33492523
Front Immunol. 2016 Dec 19;7:604
pubmed: 28066415
Eur J Intern Med. 2020 Jun;76:31-35
pubmed: 32405160
N Engl J Med. 2021 Jan 21;384(3):238-251
pubmed: 33332778
Lancet. 2020 May 22;:
pubmed: 32450107
Pharmacol Rep. 2021 Oct;73(5):1473-1479
pubmed: 33779964
Virol J. 2005 Aug 22;2:69
pubmed: 16115318
Ultrastruct Pathol. 2020 Nov 20;44(4-6):519-523
pubmed: 33274661
Annu Rev Immunol. 2013;31:705-42
pubmed: 23330954
JAMA. 2021 Jan 19;325(3):254-264
pubmed: 33464336
Microbiol Mol Biol Rev. 2012 Mar;76(1):16-32
pubmed: 22390970
J Virol. 2012 Nov;86(21):11416-24
pubmed: 22915814
Br J Pharmacol. 2007 Sep;152(1):53-61
pubmed: 17603542
N Engl J Med. 2006 Apr 20;354(16):1671-84
pubmed: 16625008
Clin Infect Dis. 2021 Dec 6;73(11):e4073-e4081
pubmed: 32674126
BMJ. 2020 Jul 30;370:m2980
pubmed: 32732190
BMJ. 2020 Jun 23;369:m2512
pubmed: 32576548
Clin Infect Dis. 2022 Mar 23;74(6):1022-1029
pubmed: 34181716
J Infect Chemother. 2021 Dec;27(12):1743-1749
pubmed: 34483029
Clin Infect Dis. 2021 Aug 2;73(3):531-534
pubmed: 32770240
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975
pubmed: 32350134
Nat Rev Drug Discov. 2011 Aug 31;10(9):712
pubmed: 21892149
Nat Rev Microbiol. 2016 Aug;14(8):523-34
pubmed: 27344959
Sci Adv. 2020 Sep 11;6(37):
pubmed: 32917717
JAMA. 2021 Apr 13;325(14):1426-1435
pubmed: 33662102
Signal Transduct Target Ther. 2020 Feb 21;5(1):18
pubmed: 32296012
JAMA. 2020 Aug 4;324(5):441-442
pubmed: 32749495
PeerJ. 2020 Nov 02;8:e10322
pubmed: 33194450
Clin Ther. 2021 Jun;43(6):1007-1019
pubmed: 34052007
Clin J Am Soc Nephrol. 2020 May 7;15(5):714-716
pubmed: 32220930
PLoS One. 2020 Nov 11;15(11):e0242184
pubmed: 33175880
Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97
pubmed: 22595692
Int J Rheum Dis. 2017 Jul;20(7):859-869
pubmed: 28160426
J Clin Virol. 2020 Jul;128:104443
pubmed: 32425661
PLoS Biol. 2005 Oct;3(10):e324
pubmed: 16128623
Lancet. 2020 Feb 15;395(10223):473-475
pubmed: 32043983
Ann N Y Acad Sci. 2002 Jun;966:290-303
pubmed: 12114286
Eur J Pharmacol. 2021 Mar 5;894:173854
pubmed: 33428898
Nat Med. 2021 Apr;27(4):717-726
pubmed: 33664494
Circ Res. 2020 Jun 5;126(12):e140-e141
pubmed: 32496917
JAMA Intern Med. 2021 Feb 1;181(2):195-202
pubmed: 33001138
Int J Biol Sci. 2020 Mar 15;16(10):1678-1685
pubmed: 32226285
J Virol. 2008 Mar;82(5):2515-27
pubmed: 18094151
Lancet Infect Dis. 2020 Aug;20(8):892-893
pubmed: 32628907
Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(7):449-463
pubmed: 28769016
J Pharm Pharm Sci. 2021;24:343-350
pubmed: 34265236
J Cardiothorac Vasc Anesth. 2021 Feb;35(2):578-584
pubmed: 33298370
Crit Care. 2004 Apr;8(2):105-7
pubmed: 15515216
Front Pharmacol. 2020 Nov 09;11:582310
pubmed: 33364957
J Transl Med. 2020 Apr 14;18(1):164
pubmed: 32290839
Nature. 2020 Jun;582(7811):289-293
pubmed: 32272481
mSystems. 2021 Oct 26;6(5):e0009521
pubmed: 34698547
Lancet. 2020 Oct 24;396(10259):1345-1352
pubmed: 33031764
Pulmonology. 2021 Jan-Feb;27(1):52-66
pubmed: 32713784
J Antibiot (Tokyo). 2017 May;70(5):495-505
pubmed: 28196978
QJM. 2020 Aug 1;113(8):546-550
pubmed: 32569363
Chem Rev. 2008 Dec;108(12):5131-45
pubmed: 19035773
J Med Virol. 2020 Jun;92(6):693-697
pubmed: 32167173
Chest. 2020 Oct;158(4):1397-1408
pubmed: 32553536
Expert Opin Drug Discov. 2019 Apr;14(4):397-412
pubmed: 30849247
JAMA Intern Med. 2020 Nov 1;180(11):1537-1539
pubmed: 32584946
Science. 2020 Jun 12;368(6496):1166-1167
pubmed: 32527806
Rheumatology (Oxford). 2011 Mar;50(3):552-62
pubmed: 21078627
Clin Ther. 1995 Jul-Aug;17(4):622-36
pubmed: 8565026
N Engl J Med. 2021 Feb 11;384(6):576-577
pubmed: 33264557
Antimicrob Agents Chemother. 2002 Apr;46(4):977-81
pubmed: 11897578
Sci Transl Med. 2015 Jun 24;7(293):293ps15
pubmed: 26109101
J Infect. 2007 Jan;54(1):28-39
pubmed: 16542729
Pharmacol Ther. 2009 Nov;124(2):195-206
pubmed: 19619582
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Lancet Respir Med. 2021 Feb;9(2):122-123
pubmed: 33189160
J Manag Care Pharm. 2010 Nov-Dec;16(9):671-9
pubmed: 21067253
JAMA. 2020 Oct 6;324(13):1292-1295
pubmed: 32876693
Lancet. 2020 Jun 13;395(10240):1820
pubmed: 32511943
N Engl J Med. 2020 Apr 23;382(17):e38
pubmed: 32268022
N Engl J Med. 2020 Nov 5;383(19):1813-1826
pubmed: 32445440
Ann Clin Microbiol Antimicrob. 2020 May 30;19(1):23
pubmed: 32473642
Am J Occup Ther. 2013 Mar-Apr;67(2):162-70
pubmed: 23433270
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
N Engl J Med. 2020 Jun 11;382(24):2327-2336
pubmed: 32275812
PLoS One. 2013 Jul 10;8(7):e68347
pubmed: 23874596
Cell Chem Biol. 2016 Jan 21;23(1):3-9
pubmed: 26933731
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Cureus. 2021 Feb 27;13(2):e13594
pubmed: 33815994
Science. 2000 Mar 17;287(5460):1960-4
pubmed: 10720314
Chest. 2020 Jul;158(1):e15-e19
pubmed: 32343968
Curr Med Res Opin. 2004 Jan;20(1):39-40
pubmed: 14741070
Trends Microbiol. 2018 Oct;26(10):865-876
pubmed: 29759926
Int J Environ Res Public Health. 2020 Jun 03;17(11):
pubmed: 32503333
Am J Ther. 2021 Apr 22;28(3):e299-e318
pubmed: 34375047
Med Mal Infect. 2020 Aug;50(5):397-400
pubmed: 32387320
BMJ. 2021 Apr 14;373:n913
pubmed: 33853842
Curr Pharm Des. 2007;13(4):405-14
pubmed: 17311557
Lancet. 2003 May 24;361(9371):1773-8
pubmed: 12781536
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):714-716
pubmed: 27913551
Trends Pharmacol Sci. 2004 Jun;25(6):291-4
pubmed: 15165741
Lancet Respir Med. 2021 Feb;9(2):196-206
pubmed: 33189161
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Curr Opin Biotechnol. 2009 Dec;20(6):708-14
pubmed: 19880308
Antimicrob Agents Chemother. 1979 Mar;15(3):372-8
pubmed: 464563
N Engl J Med. 2021 Apr 22;384(16):1503-1516
pubmed: 33631066
Lancet. 2020 Apr 4;395(10230):1111
pubmed: 32220278
N Engl J Med. 2021 Jan 7;384(1):20-30
pubmed: 33332779
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Front Microbiol. 2017 Nov 27;8:2323
pubmed: 29230203
J Chem Inf Model. 2020 Dec 28;60(12):5727-5729
pubmed: 32914973
JAMA. 2020 Apr 28;323(16):1561-1562
pubmed: 32219429
Biochem J. 1994 Jun 1;300 ( Pt 2):281-90
pubmed: 8002928
Trends Microbiol. 2015 Oct;23(10):653-665
pubmed: 26433697
J Med Chem. 2006 May 4;49(9):2845-9
pubmed: 16640347
Lancet Respir Med. 2020 Mar;8(3):220-222
pubmed: 32043984
Cell Death Differ. 2020 May;27(5):1451-1454
pubmed: 32205856
Antimicrob Agents Chemother. 2020 Aug 20;64(9):
pubmed: 32661006
Leukemia. 2020 Jun;34(6):1503-1511
pubmed: 32372026
Trends Pharmacol Sci. 2020 Nov;41(11):815-829
pubmed: 32829936
Contemp Clin Trials. 2021 Jul;106:106438
pubmed: 34000408
Chest. 2007 Sep;132(3):1093-4; author reply 1094
pubmed: 17873207
Science. 2020 Dec 4;370(6521):
pubmed: 33060197
Int J Antimicrob Agents. 2020 Jul;56(1):105949
pubmed: 32205204
Lancet Glob Health. 2020 Sep;8(9):e1125-e1126
pubmed: 32679038

Auteurs

Halie M Rando (HM)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America; Center for Health AI, University of Colorado School of Medicine, Aurora, Colorado, United States of America · Funded by the Gordon and Betty Moore Foundation (GBMF 4552).

Nils Wellhausen (N)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Soumita Ghosh (S)

Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Alexandra J Lee (AJ)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America · Funded by the Gordon and Betty Moore Foundation (GBMF 4552).

Anna Ada Dattoli (AA)

Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Fengling Hu (F)

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

James Brian Byrd (JB)

University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America · Funded by NIH K23HL128909; FastGrants.

Diane N Rafizadeh (DN)

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of AmericaFunded by NIH Medical Scientist Training Program T32 GM07170.

Ronan Lordan (R)

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5158, USA.

Yanjun Qi (Y)

Department of Computer Science, University of Virginia, Charlottesville, VA, United States of America.

Yuchen Sun (Y)

Department of Computer Science, University of Virginia, Charlottesville, VA, United States of America.

Christian Brueffer (C)

Department of Clinical Sciences, Lund University, Lund, Sweden.

Jeffrey M Field (JM)

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Marouen Ben Guebila (MB)

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America.

Nafisa M Jadavji (NM)

Biomedical Science, Midwestern University, Glendale, AZ, United States of America; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada · Funded by the American Heart Association (20AIREA35050015).

Ashwin N Skelly (AN)

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America · Funded by NIH Medical Scientist Training Program T32 GM07170.

Bharath Ramsundar (B)

The DeepChem Project, https://deepchem.io/.

Jinhui Wang (J)

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Rishi Raj Goel (RR)

Institute for Immunology, University of Pennsylvania, Philadelphia, PA, United States of America.

YoSon Park (Y)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America · Funded by NHGRI R01 HG10067.

Simina M Boca (SM)

Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, District of Columbia, United States of America; Early Biometrics & Statistical Innovation, Data Science & Artificial Intelligence, R & D, AstraZeneca, Gaithersburg, Maryland, United States of America.

Anthony Gitter (A)

Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Morgridge Institute for Research, Madison, Wisconsin, United States of America · Funded by John W. and Jeanne M. Rowe Center for Research in Virology.

Casey S Greene (CS)

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Philadelphia, Pennsylvania, United States of America; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America; Center for Health AI, University of Colorado School of Medicine, Aurora, Colorado, United States of America · Funded by the Gordon and Betty Moore Foundation (GBMF 4552); the National Human Genome Research Institute (R01 HG010067).

Classifications MeSH