Computerized physical and cognitive training improves the functional architecture of the brain in adults with Down syndrome: A network science EEG study.
Adaptive neuroplasticity
Cognitive training
Down syndrome
Electroencephalography
Network science indices
Physical training
Journal
Network neuroscience (Cambridge, Mass.)
ISSN: 2472-1751
Titre abrégé: Netw Neurosci
Pays: United States
ID NLM: 101719149
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
06
2020
accepted:
01
12
2020
entrez:
10
3
2021
pubmed:
11
3
2021
medline:
11
3
2021
Statut:
epublish
Résumé
Understanding the neuroplastic capacity of people with Down syndrome (PwDS) can potentially reveal the causal relationship between aberrant brain organization and phenotypic characteristics. We used resting-state EEG recordings to identify how a neuroplasticity-triggering training protocol relates to changes in the functional connectivity of the brain's intrinsic cortical networks. Brain activity of 12 PwDS before and after a 10-week protocol of combined physical and cognitive training was statistically compared to quantify changes in directed functional connectivity in conjunction with psychosomatometric assessments. PwDS showed increased connectivity within the left hemisphere and from left-to-right hemisphere, as well as increased physical and cognitive performance. Our findings reveal a strong adaptive neuroplastic reorganization as a result of the training that leads to a less-random network with a more pronounced hierarchical organization. Our results go beyond previous findings by indicating a transition to a healthier, more efficient, and flexible network architecture, with improved integration and segregation abilities in the brain of PwDS. Resting-state electrophysiological brain activity is used here for the first time to display meaningful relationships to underlying Down syndrome processes and outcomes of importance in a translational inquiry. This trial is registered with ClinicalTrials.gov Identifier NCT04390321.
Identifiants
pubmed: 33688615
doi: 10.1162/netn_a_00177
pii: netn_a_00177
pmc: PMC7935030
doi:
Banques de données
ClinicalTrials.gov
['NCT04390321']
Types de publication
Journal Article
Langues
eng
Pagination
274-294Informations de copyright
© 2020 Massachusetts Institute of Technology.
Références
Nature. 1998 Jun 4;393(6684):440-2
pubmed: 9623998
Trends Cogn Sci. 2018 Jan;22(1):8-20
pubmed: 29167088
J Clin Neurophysiol. 2002 Apr;19(2):113-24
pubmed: 11997722
Clin Neurophysiol. 2010 Aug;121(8):1205-12
pubmed: 20362500
Int J Psychophysiol. 1994 Oct;18(1):49-65
pubmed: 7876038
Front Aging Neurosci. 2015 Aug 07;7:152
pubmed: 26300772
PLoS One. 2010 Nov 01;5(11):e13788
pubmed: 21072180
Neuroimage. 2003 Sep;20(1):393-403
pubmed: 14527599
Neuropsychologia. 2006;44(12):2564-8
pubmed: 16797613
Hum Brain Mapp. 2020 Feb 1;41(2):362-372
pubmed: 31587450
Sci Rep. 2019 Dec 17;9(1):19290
pubmed: 31848397
Front Neurosci. 2016 Feb 29;10:55
pubmed: 26973445
Am J Med Genet A. 2011 Aug;155A(8):1939-48
pubmed: 21739598
Neuroimage Clin. 2013 May 24;2:703-15
pubmed: 24179822
Neuroscientist. 2006 Dec;12(6):512-23
pubmed: 17079517
Brain Connect. 2015 Oct;5(8):461-75
pubmed: 25712025
Trends Neurosci. 2007 Sep;30(9):464-72
pubmed: 17765329
Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007178
pubmed: 19160328
Comput Intell Neurosci. 2011;2011:156869
pubmed: 21253357
Neuroimage. 2010 Dec;53(4):1197-207
pubmed: 20600983
IEEE J Biomed Health Inform. 2017 May;21(3):859-866
pubmed: 28113566
Cogn Neurodyn. 2013 Aug;7(4):333-40
pubmed: 24427209
Nat Rev Neurosci. 2012 Dec;13(12):844-58
pubmed: 23165261
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
pubmed: 17167157
PLoS Comput Biol. 2016 May 09;12(5):e1004858
pubmed: 27159884
Am J Med Genet A. 2010 Dec;152A(12):3028-35
pubmed: 21108390
Front Behav Neurosci. 2015 Sep 11;9:232
pubmed: 26441566
Age Ageing. 1997 Jan;26(1):15-9
pubmed: 9143432
Arch Phys Med Rehabil. 2007 Jan;88(1):99-104
pubmed: 17207683
PLoS One. 2013 Jul 04;8(7):e68910
pubmed: 23861951
Am J Psychiatry. 2001 Oct;158(10):1659-65
pubmed: 11578999
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3316-21
pubmed: 14978288
PLoS One. 2008 Apr 30;3(4):e0002051
pubmed: 18446219
Annu Rev Psychol. 2016;67:613-40
pubmed: 26393868
J Gerontol. 1994 Mar;49(2):M85-94
pubmed: 8126356
Acta Neurol Scand. 1997 Oct;96(4):236-40
pubmed: 9325475
Stud Health Technol Inform. 2018;251:15-18
pubmed: 29968590
J Am Geriatr Soc. 2009 Apr;57(4):594-603
pubmed: 19220558
Cortex. 2015 Mar;64:148-56
pubmed: 25461715
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Neurobiol Aging. 2019 Dec;84:70-79
pubmed: 31518951
Physiol Rev. 2009 Jul;89(3):887-920
pubmed: 19584316
Neural Plast. 2011;2011:286073
pubmed: 21766040
Res Dev Disabil. 2016 Oct;57:181-92
pubmed: 27448331
J Intellect Disabil Res. 2019 Aug;63(8):1041-1067
pubmed: 30788876
Behav Genet. 2011 May;41(3):381-93
pubmed: 21279430
Neuroimage. 2008 Feb 1;39(3):1324-32
pubmed: 18006337
Neural Plast. 2015;2015:172192
pubmed: 25945260
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12522-7
pubmed: 26371305
Clin Neurophysiol. 2013 Sep;124(9):1755-64
pubmed: 23583023
J Child Psychol Psychiatry. 2001 Feb;42(2):241-51
pubmed: 11280420
J Neurosci Methods. 2013 Jan 15;212(1):133-42
pubmed: 23085279
J Child Psychol Psychiatry. 1997 Oct;38(7):813-22
pubmed: 9363580
Dev Neurosci. 2011;33(5):414-27
pubmed: 21893967
PLoS Comput Biol. 2007 Feb 2;3(2):e17
pubmed: 17274684
Hum Brain Mapp. 2002 Jan;15(1):1-25
pubmed: 11747097
Neuroimage. 2014 Jan 15;85 Pt 2:853-72
pubmed: 24007803
Brain Cogn. 1994 Nov;26(2):191-5
pubmed: 7857609
Nat Rev Neurosci. 2012 Apr 13;13(5):336-49
pubmed: 22498897
Physiol Res. 1999;48(2):87-97
pubmed: 10534011
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Dement Geriatr Cogn Dis Extra. 2015 Sep 18;5(3):330-40
pubmed: 26483832
Res Dev Disabil. 2017 Mar;62:81-103
pubmed: 28119223
Clin Neurophysiol. 2009 Sep;120(9):1619-27
pubmed: 19643663
J Intellect Disabil Res. 2019 Sep;63(9):1137-1150
pubmed: 31062455
Neurosci Biobehav Rev. 2014 Jul;44:206-20
pubmed: 24705268
Nature. 1999 Jul 29;400(6743):418-9
pubmed: 10440369
Phys Ther. 2000 Sep;80(9):896-903
pubmed: 10960937
Cereb Cortex. 2007 Jan;17(1):92-9
pubmed: 16452642
Neuroimage. 2004 Sep;23(1):54-63
pubmed: 15325352
J Alzheimers Dis. 2007 Mar;11(1):61-76
pubmed: 17361036
Neural Comput. 1999 Feb 15;11(2):417-41
pubmed: 9950738
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Phys Rev Lett. 2001 Nov 5;87(19):198701
pubmed: 11690461