Spermidine supplementation in rare translation-associated disorders.

Kabuki syndrome eIF5A hypusination rare disease spermidine translation

Journal

Cell stress

ISSN: 2523-0204

Titre abrégé: Cell Stress

Pays: Austria

ID NLM: 101718867

Informations de publication

Date de publication:
08 Mar 2021

Historique:

entrez: 10 3 2021

pubmed: 11 3 2021

medline: 11 3 2021

Statut: epublish

Résumé

The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced immune cell function through insufficient eIF5A hypusination, which can be restored by external supplementation. Recent findings characterize a group of novel Mendelian disorders linked to

Identifiants

DOI: 10.15698/cst2021.03.243 PMID: 33688620 PMC: PMC7921850

pubmed: 33688620

doi: 10.15698/cst2021.03.243

pii: CST0271E115

pmc: PMC7921850

doi:

Types de publication

Journal Article Comment

Langues

eng

Pagination

29-32

Commentaires et corrections

Type : CommentOn

Informations de copyright

Déclaration de conflit d'intérêts

Conflict of Interest: D.C.-G. and F.M. have equity interests in The Longevity Labs (TLL), a company founded in 2016 that develops natural food extracts.

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