Effect of soak and smear on [14C]-hydrocortisone

Carbon Radioisotopes / metabolism Epidermis / metabolism Humans Hydrocortisone / pharmacology Skin Skin Absorption Water / metabolism
Soak and smear hydrocortisone in vitro human skin percutaneous penetration

Journal

The Journal of dermatological treatment
ISSN: 1471-1753
Titre abrégé: J Dermatolog Treat
Pays: England
ID NLM: 8918133

Informations de publication

Date de publication:
May 2022
Historique:
pubmed: 11 3 2021
medline: 10 6 2022
entrez: 10 3 2021
Statut: ppublish

Résumé

'Soak and smear' method, water soaking to induce skin hydration followed by topical corticoids application suggests effectiveness in clinical dermatological practice. We investigate one possible mechanism of soaking times effect on drug partitioning and diffusion rates in skin and its proposed efficacy. Utilizing an In water-soak groups, more [ Effect of 'soak and smear' on skin absorption and penetration depends on interaction of individual drug's physicochemical property, stratum corneum hydration, and stratum corneum-epidermoid barrier status. Water soaking (

Identifiants

DOI: 10.1080/09546634.2021.1900531 PMID: 33689537
pubmed: 33689537
doi: 10.1080/09546634.2021.1900531
doi:

Substances chimiques

Carbon Radioisotopes 0
Water 059QF0KO0R
Carbon-14 7V68J5677O
Hydrocortisone WI4X0X7BPJ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1696-1702

Auteurs

Xiaoying Hui (X)

Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.

Howard I Maibach (HI)

Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Effect of soak and smear on [14C]-hydrocortisone
questionsmedicales.fr › Système tégumentaire › Peau › Épiderme › Effect of soak and smear on [14C]-hydrocortisone
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of soak and smear on [14C]-hydrocortisone
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › Effect of soak and smear on [14C]-hydrocortisone
questionsmedicales.fr › Système tégumentaire › Peau › Effect of soak and smear on [14C]-hydrocortisone
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Absorption cutanée › Effect of soak and smear on [14C]-hydrocortisone
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Effect of soak and smear on [14C]-hydrocortisone