Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation.
Ataxin-2
D. melanogaster
TRIBE
cell biology
mRNA
neurodegeneration
neuroscience
rnp granule
translational control
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 03 2021
10 03 2021
Historique:
received:
23
06
2020
accepted:
23
02
2021
entrez:
10
3
2021
pubmed:
11
3
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with structured domains to enable positive and negative regulation of target mRNAs remains unclear. Using the Targets of RNA-Binding Proteins Identified by Editing technology, we identified an extensive data set of Atx2-target mRNAs in the
Identifiants
pubmed: 33689682
doi: 10.7554/eLife.60326
pii: 60326
pmc: PMC7946432
doi:
pii:
Substances chimiques
ATX2 protein, Drosophila
0
Ataxin-2
0
Drosophila Proteins
0
RNA, Messenger
0
RNA-Binding Proteins
0
Banques de données
GEO
['GSE153985', 'GSM2065948']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/I/19/1/504286
Pays : India
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2021, Singh et al.
Déclaration de conflit d'intérêts
AS, JH, AK, SP, JH, AP, KA, KR, DT, DJ, BB No competing interests declared, KV Senior editor, eLife, MR Reviewing editor, eLife
Références
Adv Exp Med Biol. 2018;1049:175-195
pubmed: 29427103
Genome Res. 2013 May;23(5):812-25
pubmed: 23520388
Science. 1991 Feb 8;251(4994):675-8
pubmed: 1899488
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nat Rev Cancer. 2011 Aug 05;11(9):644-56
pubmed: 21822212
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2734-2739
pubmed: 29483269
Cell. 2015 Aug 27;162(5):1066-77
pubmed: 26317470
Eur J Biochem. 2004 Aug;271(15):3155-70
pubmed: 15265035
Nature. 2017 Jun 8;546(7657):243-247
pubmed: 28562589
RNA. 2014 Aug;20(8):1298-319
pubmed: 24942623
Nature. 2017 Apr 20;544(7650):362-366
pubmed: 28405024
Mol Cell. 2001 Jun;7(6):1191-200
pubmed: 11430822
Cerebellum. 2008;7(2):115-24
pubmed: 18418684
Cell. 2018 Aug 9;174(4):791-802
pubmed: 30096311
Cell. 2019 Apr 18;177(3):711-721.e8
pubmed: 30982603
J Cell Biol. 2013 Apr 29;201(3):361-72
pubmed: 23629963
Mol Cell. 2014 Jul 17;55(2):186-98
pubmed: 24954906
EMBO J. 1998 Jun 15;17(12):3461-70
pubmed: 9628881
NAR Genom Bioinform. 2020 Sep 22;2(3):lqaa073
pubmed: 33575621
Nat Rev Neurosci. 2015 Feb;16(2):109-20
pubmed: 25588378
Nat Rev Neurol. 2019 May;15(5):272-286
pubmed: 30890779
Nucleic Acids Res. 2010 Jan;38(1):239-52
pubmed: 19850724
Neuron. 2018 May 16;98(4):754-766.e4
pubmed: 29772202
Biomed Res Int. 2016;2016:8367534
pubmed: 27239475
Int J Mol Sci. 2019 Nov 21;20(23):
pubmed: 31766565
Neuron. 2018 May 16;98(4):673-675
pubmed: 29772196
Cell Rep. 2020 Mar 10;30(10):3353-3367.e7
pubmed: 32160542
Development. 2004 Oct;131(19):4831-41
pubmed: 15342467
Annu Rev Biochem. 2018 Jun 20;87:351-390
pubmed: 29195049
Cell. 2015 Nov 5;163(4):829-39
pubmed: 26544936
Genome Biol. 2014;15(12):550
pubmed: 25516281
Biochim Biophys Acta. 2016 Sep;1862(9):1558-69
pubmed: 27240544
Cell. 2016 Apr 21;165(3):742-53
pubmed: 27040499
Elife. 2021 Mar 10;10:
pubmed: 33689682
Hum Mol Genet. 2011 May 1;20(9):1697-700
pubmed: 21292779
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2987-92
pubmed: 14981256
PLoS Genet. 2015 Apr 22;11(4):e1005182
pubmed: 25902068
Mol Biol Cell. 2007 Apr;18(4):1385-96
pubmed: 17392519
Mol Cell. 2017 Apr 6;66(1):129-140.e7
pubmed: 28388438
Cell. 2019 Apr 18;177(3):697-710.e17
pubmed: 30982600
Front Mol Biosci. 2017 Oct 23;4:71
pubmed: 29109951
iScience. 2020 Jul 24;23(7):101318
pubmed: 32674054
Science. 2013 May 17;340(6134):875-9
pubmed: 23687047
Hum Mol Genet. 2006 Aug 15;15(16):2523-32
pubmed: 16835262
PLoS One. 2010 Apr 02;5(4):e10006
pubmed: 20368989
Neurol India. 1977 Sep;25(3):147-60
pubmed: 613260
J Biol Chem. 2020 Nov 20;295(47):15810-15825
pubmed: 32989052
Nat Rev Neurosci. 2019 Nov;20(11):649-666
pubmed: 31582840
PLoS Biol. 2018 Jul 3;16(7):e2005970
pubmed: 29969450
Front Genet. 2019 May 02;10:332
pubmed: 31118942
J Mol Biol. 2005 Feb 11;346(1):203-14
pubmed: 15663938
Front Genet. 2019 Jan 24;10:6
pubmed: 30740123
Brain Res. 1992 Jul 10;585(1-2):386-90
pubmed: 1511324
Chronobiol Int. 2017;34(1):129-137
pubmed: 27791392
Cell. 2013 Aug 15;154(4):727-36
pubmed: 23953108
Sci Adv. 2020 Aug 12;6(33):eabb8771
pubmed: 32851185
Bioessays. 2014 Jan;36(1):39-45
pubmed: 24115048
Cell. 2020 Apr 16;181(2):306-324.e28
pubmed: 32302570
Arch Neurol. 2011 Jun;68(6):739-42
pubmed: 21670397
Brain. 1971;94(2):359-74
pubmed: 5571047
Trends Biochem Sci. 2015 Nov;40(11):662-672
pubmed: 26481498
Bioinformatics. 2009 May 1;25(9):1105-11
pubmed: 19289445
Cell. 2012 May 11;149(4):753-67
pubmed: 22579281
EMBO J. 2016 Aug 1;35(15):1603-12
pubmed: 27357569
J Cell Biol. 2017 Aug 7;216(8):2235-2237
pubmed: 28667121
Cerebellum. 2017 Feb;16(1):68-81
pubmed: 26868665
Science. 2006 May 19;312(5776):1051-4
pubmed: 16614170
J Virol. 2019 May 29;93(12):
pubmed: 30944179
Cell. 2020 Apr 16;181(2):346-361.e17
pubmed: 32302572
Cell. 2017 Oct 19;171(3):615-627.e16
pubmed: 28942918
Cell Rep. 2017 Aug 29;20(9):2277
pubmed: 28854374
Nature. 2010 Aug 26;466(7310):1069-75
pubmed: 20740007
Methods Mol Biol. 2007;362:375-7
pubmed: 17417024
Mol Cell Proteomics. 2016 May;15(5):1728-39
pubmed: 26850065
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E99-E108
pubmed: 24344294
FEBS J. 2013 Sep;280(18):4348-70
pubmed: 23587065
Traffic. 2019 Jun;20(6):436-447
pubmed: 30989774
PLoS Genet. 2012 Jan;8(1):e1002433
pubmed: 22242014
Exp Neurol. 2009 Jan;215(1):110-8
pubmed: 18973756
Nat Rev Mol Cell Biol. 2018 May;19(5):327-341
pubmed: 29339797
Nature. 2017 Apr 20;544(7650):367-371
pubmed: 28405022
Science. 2013 May 17;340(6134):879-82
pubmed: 23687048
RNA. 2018 Feb;24(2):173-182
pubmed: 29127211
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8
pubmed: 19458158
Nat Protoc. 2018 Aug;13(8):1829-1849
pubmed: 30013039
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):E655-62
pubmed: 21795609