Lipopolysaccharide influences the plasma and brain pharmacokinetics of subcutaneously-administered HsTX1[R14A], a K

Animals Brain / metabolism Chromatography, Liquid Kv1.3 Potassium Channel / metabolism Lipopolysaccharides / toxicity Mice Mice, Inbred C57BL Peptides Plasma Potassium Channel Blockers Scorpion Venoms / toxicity Tandem Mass Spectrometry
Blood-brain barrier (BBB) Central nervous system (CNS) Liquid chromatography-mass spectrometry (LC-MS) Peptide delivery Pharmacokinetics

Journal

Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333

Informations de publication

Date de publication:
May 2021
Historique:
received: 14 12 2020
revised: 22 02 2021
accepted: 03 03 2021
pubmed: 11 3 2021
medline: 13 5 2021
entrez: 10 3 2021
Statut: ppublish

Résumé

K

Identifiants

DOI: 10.1016/j.toxicon.2021.03.002 PMID: 33689790
pubmed: 33689790
pii: S0041-0101(21)00075-1
doi: 10.1016/j.toxicon.2021.03.002
pii:
doi:

Substances chimiques

Kv1.3 Potassium Channel 0
Lipopolysaccharides 0
Peptides 0
Potassium Channel Blockers 0
Scorpion Venoms 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-36

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Sanjeevini Babu Reddiar (SB)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Liang Jin (L)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Dorothy C C Wai (DCC)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Agota Csoti (A)

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Hungary.

Gyorgy Panyi (G)

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Hungary.

Raymond S Norton (RS)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria, Australia.

Joseph A Nicolazzo (JA)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: joseph.nicolazzo@monash.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.3 › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux potassiques › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Venins de scorpion › Lipopolysaccharide influences the plasma and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Lipopolysaccharide influences the plasma and...