The role of Tetrahydrocannabinol in inducing disrupted signaling cascades, hippocampal atrophy and memory defects.
Hippocampus
Neurodegeneration
RNA-seq
Tetrahydrocannabinol
Journal
Journal of chemical neuroanatomy
ISSN: 1873-6300
Titre abrégé: J Chem Neuroanat
Pays: Netherlands
ID NLM: 8902615
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
10
10
2020
revised:
23
02
2021
accepted:
02
03
2021
pubmed:
11
3
2021
medline:
2
10
2021
entrez:
10
3
2021
Statut:
ppublish
Résumé
Tetrahydrocannabinol (THC), a major psychoactive constituent of marijuana, can substantially change the function of several brain areas, leading to behavioral impairment including memory and learning dysfunction. Given the importance of hippocampus as one of the chief parts of the brain involved in memory processing, the present study seeks to investigate structural and histological alterations in hippocampus as well as behavioral defects provoked by THC treatment. Besides, using genome-wide sequencing, we adopted a pathway-based approach to discover dysregulated molecular pathways. Our results demonstrated remarkable hippocampal atrophy, and also interrupted memory function and long term potentiation (LTP) under THC exposure. We also detected several dysregulated signaling pathways involved in synaptic plasticity as well as cell-cell interaction in the hippocampus of THC-treated rats. Overall, the results indicate a potential correlation between disrupted signaling cascades, hippocampal atrophy and memory defects caused by THC treatment.
Identifiants
pubmed: 33689904
pii: S0891-0618(21)00026-0
doi: 10.1016/j.jchemneu.2021.101943
pii:
doi:
Substances chimiques
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101943Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.