Epigenetic regulation of cellular functions in wound healing.
DNA methylation
circRNA
histone modification
lncRNA
miRNA
skin wound healing
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
04
03
2021
received:
08
01
2021
accepted:
08
03
2021
pubmed:
11
3
2021
medline:
31
3
2022
entrez:
10
3
2021
Statut:
ppublish
Résumé
Stringent spatiotemporal regulation of the wound healing process involving multiple cell types is associated with epigenetic mechanisms of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, as well as non-coding RNAs. Here, we discuss the epigenetic changes that occur during wound healing and the rapidly expanding understanding of how these mechanisms affect healing resolution in both acute and chronic wound milieu. We provide a focussed overview of current research into epigenetic regulators that contribute to wound healing by specific cell type. We highlight the role of epigenetic regulators in the molecular pathophysiology of chronic wound conditions. The understanding of how epigenetic regulators can affect cellular functions during normal and impaired wound healing could lead to novel therapeutic approaches, and we outline questions that can provide guidance for future research on epigenetic-based interventions to promote healing. Dissecting the dynamic interplay between cellular subtypes involved in wound healing and epigenetic parameters during barrier repair will deepen our understanding of how to improve healing outcomes in patients affected by chronic non-healing wounds.
Identifiants
pubmed: 33690920
doi: 10.1111/exd.14325
pmc: PMC8324509
mid: NIHMS1684005
doi:
Substances chimiques
Histones
0
MicroRNAs
0
RNA, Circular
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1073-1089Subventions
Organisme : NINR NIH HHS
ID : R01 NR013881
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK119085
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR015649
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073614
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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