Discovery of Bivalent GalNAc-Conjugated Betulin as a Potent ASGPR-Directed Agent against Hepatocellular Carcinoma.

Acetylgalactosamine / chemistry Antineoplastic Agents / chemistry Asialoglycoprotein Receptor / drug effects Carcinoma, Hepatocellular / pathology Cell Line, Tumor Drug Delivery Systems Drug Discovery Drug Screening Assays, Antitumor Fluorescent Dyes / chemistry Humans Hydrophobic and Hydrophilic Interactions Liver Neoplasms / pathology Molecular Docking Simulation Surface Plasmon Resonance Triterpenes / chemistry

Journal

Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319

Informations de publication

Date de publication:
21 04 2021
Historique:
pubmed: 12 3 2021
medline: 15 9 2021
entrez: 11 3 2021
Statut: ppublish

Résumé

Herein, we describe the design, synthesis, and biological evaluation of novel betulin and

Identifiants

DOI: 10.1021/acs.bioconjchem.1c00042 PMID: 33691403
pubmed: 33691403
doi: 10.1021/acs.bioconjchem.1c00042
doi:

Substances chimiques

Antineoplastic Agents 0
Asialoglycoprotein Receptor 0
Fluorescent Dyes 0
Triterpenes 0
betulin 6W70HN7X7O
Acetylgalactosamine KM15WK8O5T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

763-781

Auteurs

Emil Yu Yamansarov (EY)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
National University of Science and Technology MISiS, Moscow 119049, Russian Federation.
Bashkir State University, Ufa 450076, Russian Federation.
ORCID: 0000-0003-1238-6273

Elena V Lopatukhina (EV)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.

Sergei A Evteev (SA)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.

Dmitry A Skvortsov (DA)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.

Anton V Lopukhov (AV)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
ORCID: 0000-0002-3517-505X

Sergey V Kovalev (SV)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
ORCID: 0000-0002-5669-8335

Alexander N Vaneev (AN)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
National University of Science and Technology MISiS, Moscow 119049, Russian Federation.
ORCID: 0000-0001-8201-8498

Dmitry O Shkil' (DO)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
ORCID: 0000-0003-3336-4815

Roman A Akasov (RA)

National University of Science and Technology MISiS, Moscow 119049, Russian Federation.
ORCID: 0000-0001-6486-8114

Alexander N Lobov (AN)

Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa 450054, Russian Federation.
ORCID: 0000-0002-9223-508X

Victor A Naumenko (VA)

V. Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow 119034, Russian Federation.
ORCID: 0000-0003-0192-4574

Ekaterina N Pavlova (EN)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.

Oxana O Ryabaya (OO)

Department of Experimental Diagnostic and Tumor Therapy, N. N. Blokhin National Medical Research Center for Oncology, Moscow 115478, Russian Federation.

Olga Yu Burenina (OY)

Skolkovo Institute of Science and Technology, Skolkovo 143026, Russian Federation.

Yan A Ivanenkov (YA)

The Federal State Unitary Enterprise Dukhov Automatics Research Institute, Moscow 127055, Russian Federation.
Institute of Biochemistry and Genetics, Russian Academy of Science (IBG RAS) of the Ufa Federal Research Centre, Ufa 450054, Russian Federation.
ORCID: 0000-0002-8968-0879

Natalia L Klyachko (NL)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
Skolkovo Institute of Science and Technology, Skolkovo 143026, Russian Federation.
ORCID: 0000-0002-9357-8236

Alexander S Erofeev (AS)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
National University of Science and Technology MISiS, Moscow 119049, Russian Federation.

Petr V Gorelkin (PV)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
National University of Science and Technology MISiS, Moscow 119049, Russian Federation.

Elena K Beloglazkina (EK)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.

Alexander G Majouga (AG)

Lomonosov Moscow State University, Moscow 119991, Russian Federation.
National University of Science and Technology MISiS, Moscow 119049, Russian Federation.
Dmitry Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russian Federation.
ORCID: 0000-0002-5184-5551

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Classifications MeSH

questionsmedicales.fr › Glucides › Osamines › Hexosamine › Galactosamine › Acétyl-galactosamine › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs des asialoglycoprotéines › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Résonance plasmonique de surface › Discovery of Bivalent GalNAc-Conjugated...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Discovery of Bivalent GalNAc-Conjugated...