Microneedle-assisted genome editing: A transdermal strategy of targeting


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
03 2021
Historique:
received: 22 09 2020
accepted: 26 01 2021
entrez: 11 3 2021
pubmed: 12 3 2021
medline: 19 4 2022
Statut: epublish

Résumé

We report a dissolvable microneedle (MN) patch that can mediate transdermal codelivery of CRISPR-Cas9-based genome-editing agents and glucocorticoids for the effective treatment of inflammatory skin disorders (ISDs). The MN is loaded with polymer-encapsulated Cas9 ribonucleoprotein (RNP) targeting

Identifiants

pubmed: 33692106
pii: 7/11/eabe2888
doi: 10.1126/sciadv.abe2888
pmc: PMC7946375
pii:
doi:

Substances chimiques

NLR Family, Pyrin Domain-Containing 3 Protein 0
Nlrp3 protein, mouse 0
Polymers 0
Ribonucleoproteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Tao Wan (T)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Qi Pan (Q)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Yuan Ping (Y)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. pingy@zju.edu.cn.

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Classifications MeSH