Age-Related Cognitive Decline and the Olfactory Identification Deficit Are Associated to Increased Level of Depression.
age
cognitive function
depression
gender differences
olfaction
smell
taste
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
08
2020
accepted:
18
01
2021
entrez:
11
3
2021
pubmed:
12
3
2021
medline:
12
3
2021
Statut:
epublish
Résumé
Previous studies reported a correlation between olfactory function and depression. However, in literature, no data are available for the correlation between depression and all other factors such as age, sex, olfactory, gustatory, and cognitive function in healthy subjects taken together. The aim of this study was to provide a systematic account regarding the association between those variables in a non-clinical population. Two hundred and seventy-three participants were recruited with an age range of 19-84 years. Olfactory, gustatory, cognitive function, and depression level were evaluated by means of the following tests: the Sniffin' Sticks test, Taste Strips test, Montreal Cognitive Assessment (MoCA), and Beck Depression Inventory (BDI). In our data, an age-related decrease in olfactory and gustatory function and a decline in cognitive functions such as attention, memory, and language were observed. Instead, no significant differences were observed for the depression level in relation to the different age ranges. However, our results indicated that the depression level could be associated to sex, odor identification impairment, and decreased attention and language. Sex, the odor identification impairment, and an age-related decrease in attention and language are associated with increased level of depression in healthy subjects. Our data can be useful and informative for health care workers, that is, to have adequate preventive strategies to be used whenever these conditions are detected and recognized.
Identifiants
pubmed: 33692667
doi: 10.3389/fnins.2021.599593
pmc: PMC7937898
doi:
Types de publication
Journal Article
Langues
eng
Pagination
599593Informations de copyright
Copyright © 2021 Sanna, Loy, Piras, Moat and Masala.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
JAMA. 2013 Jan 2;309(1):71-82
pubmed: 23280227
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189
pubmed: 22229116
Ann Otol Rhinol Laryngol. 2003 Nov;112(11):971-8
pubmed: 14653367
Psychopharmacology (Berl). 2019 Oct;236(10):3063-3079
pubmed: 31359117
J Laryngol Otol. 2013 Dec;127(12):1156-9
pubmed: 24280062
Chem Senses. 1997 Feb;22(1):39-52
pubmed: 9056084
Int J Methods Psychiatr Res. 2003;12(1):3-21
pubmed: 12830306
Neuroimage. 2014 Sep;98:289-95
pubmed: 24825502
Neurosci Biobehav Rev. 2008 Sep;32(7):1315-25
pubmed: 18555528
Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Jan;128(1):18-23
pubmed: 21227767
Psychiatry Res. 2011 Dec 30;190(2-3):217-20
pubmed: 21940053
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Sleep Med Rev. 2019 Feb;43:37-46
pubmed: 30503716
J Neurol. 2018 Aug;265(8):1764-1771
pubmed: 29804147
Chem Senses. 2014 Mar;39(3):185-94
pubmed: 24429163
Physiol Behav. 2009 May 25;97(2):213-28
pubmed: 19272398
Neuroscience. 2013 Aug 29;246:199-229
pubmed: 23644052
J Neurol. 2010 Aug;257(8):1303-8
pubmed: 20221768
Neurol Sci. 2015 Feb;36(2):209-14
pubmed: 25139107
J Neurol. 2020 Jan;267(1):57-63
pubmed: 31555978
Anat Rec. 1998 Jul;251(3):326-9
pubmed: 9669759
J Neural Transm (Vienna). 2019 May;126(5):585-595
pubmed: 30911822
J Neurol. 2009 Feb;256(2):242-8
pubmed: 19221845
Lancet Psychiatry. 2017 Feb;4(2):146-158
pubmed: 27856392
Neuroimage. 2008 Aug 15;42(2):498-502
pubmed: 18555701
Laryngorhinootologie. 2007 Sep;86(9):640-3
pubmed: 17806002
Rhinology. 2011 Aug;49(3):324-30
pubmed: 21858264
Postgrad Med J. 2006 Apr;82(966):239-41
pubmed: 16597809
Front Psychol. 2014 Feb 07;5:20
pubmed: 24570664
J Psychiatr Res. 2001 Sep-Oct;35(5):271-7
pubmed: 11591429
Neuropsychiatr Dis Treat. 2019 May 10;15:1249-1258
pubmed: 31190831
Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1649-1654
pubmed: 30843174
Eur Arch Otorhinolaryngol. 2007 Mar;264(3):237-43
pubmed: 17021776
Eur Arch Otorhinolaryngol. 2019 Mar;276(3):719-728
pubmed: 30554358
J Neurosci Res. 2017 Jan 2;95(1-2):737-762
pubmed: 27870440
Horm Behav. 2006 Nov;50(4):534-8
pubmed: 16920114
Facial Plast Surg. 2017 Aug;33(4):396-404
pubmed: 28753713
Transl Psychiatry. 2019 Feb 14;9(1):88
pubmed: 30765686
Behav Neurosci. 2010 Apr;124(2):256-64
pubmed: 20364885
BMC Public Health. 2007 Sep 30;7:269
pubmed: 17903273
Rhinology. 2003 Mar;41(1):2-6
pubmed: 12677732
Brain Sci. 2020 Apr 07;10(4):
pubmed: 32272584
Neuroscience. 2010 Aug 11;169(1):415-21
pubmed: 20472036
J Affect Disord. 2014 May;160:80-6
pubmed: 24445134
Laryngoscope Investig Otolaryngol. 2018 Feb 21;3(2):94-99
pubmed: 29721540
Dialogues Clin Neurosci. 2001 Sep;3(3):217-28
pubmed: 22034198
Int J Epidemiol. 2015 Oct;44(5):1696-705
pubmed: 26208807
Ann Neurol. 2005 Jul;58(1):155-60
pubmed: 15984022
Biol Res Nurs. 2018 Jul;20(4):383-392
pubmed: 29759000
Brain Res Bull. 1987 May;18(5):597-600
pubmed: 3607528
J Affect Disord. 2016 Jan 15;190:193-207
pubmed: 26519640
J Behav Med. 2003 Apr;26(2):119-32
pubmed: 12776382
Laryngoscope. 2010 Apr;120(4):826-31
pubmed: 20213799
J Pharm Bioallied Sci. 2014 Jul;6(Suppl 1):S30-3
pubmed: 25210380
Postgrad Med J. 2006 Feb;82(964):84-8
pubmed: 16461469