Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review.
breast cancer
cytokeratin 7-negative
metastatic orbital tumor
neuroendocrine differentiation
visual function
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
11
2020
accepted:
06
01
2021
entrez:
11
3
2021
pubmed:
12
3
2021
medline:
18
12
2021
Statut:
epublish
Résumé
Orbital metastases from cancers of various organs can arise A woman in her fifties visited our ophthalmology department with a chief complaint of foreign body sensation and exophthalmos in her right eye. An elastic soft mass was palpated from the lateral orbit to the temporal region. A systemic examination revealed breast cancer and a metastatic orbital tumor. Excisional biopsy of the breast revealed a diagnosis of invasive ductal carcinoma with neuroendocrine differentiation, and immunohistochemical examination was negative for cytokeratin 7, making the case unusual. Chemotherapy was remarkably effective, and the tumor size decreased, resulting in improvement of visual function. Her general condition and quality of life are still good at present. We searched the PubMed English language literature focusing on metastatic orbital tumors from breast cancer in which ocular symptoms had been the initial presenting sign. No previous reports have documented neuroendocrine differentiation or cytokeratin 7 expression in isolated orbital metastases from breast cancer. Although it is not possible to be certain from this case alone, we speculated that some such cases might involve cytokeratin 7-negative invasive breast cancer with neuroendocrine differentiation. We have described our experience of a very rare case of cytokeratin 7 negative breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and formed a solitary giant tumor initially manifesting as ocular symptoms.
Sections du résumé
Background
Orbital metastases from cancers of various organs can arise
Case Presentation
A woman in her fifties visited our ophthalmology department with a chief complaint of foreign body sensation and exophthalmos in her right eye. An elastic soft mass was palpated from the lateral orbit to the temporal region. A systemic examination revealed breast cancer and a metastatic orbital tumor. Excisional biopsy of the breast revealed a diagnosis of invasive ductal carcinoma with neuroendocrine differentiation, and immunohistochemical examination was negative for cytokeratin 7, making the case unusual. Chemotherapy was remarkably effective, and the tumor size decreased, resulting in improvement of visual function. Her general condition and quality of life are still good at present. We searched the PubMed English language literature focusing on metastatic orbital tumors from breast cancer in which ocular symptoms had been the initial presenting sign. No previous reports have documented neuroendocrine differentiation or cytokeratin 7 expression in isolated orbital metastases from breast cancer. Although it is not possible to be certain from this case alone, we speculated that some such cases might involve cytokeratin 7-negative invasive breast cancer with neuroendocrine differentiation.
Conclusion
We have described our experience of a very rare case of cytokeratin 7 negative breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and formed a solitary giant tumor initially manifesting as ocular symptoms.
Identifiants
pubmed: 33692758
doi: 10.3389/fendo.2021.625663
pmc: PMC7937957
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
625663Informations de copyright
Copyright © 2021 Togashi, Nishitsuka, Hayashi, Namba, Goto, Takeda, Suzuki, Kato, Yamada, Konno, Yoshioka, Yamakawa, Sonoda, Suzuki and Yamashita.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Ophthalmology. 2004 May;111(5):997-1008
pubmed: 15121380
BMC Cancer. 2019 Jan 8;19(1):36
pubmed: 30621656
Ophthalmic Plast Reconstr Surg. 2013 Jul-Aug;29(4):e98-e101
pubmed: 23446302
Neuroradiology. 2004 Aug;46(8):682-5
pubmed: 15243723
Int J Hyperthermia. 2004 Feb;20(1):1-6
pubmed: 14612310
Mol Oncol. 2010 Jun;4(3):192-208
pubmed: 20452298
Ophthalmic Plast Reconstr Surg. 2014 Mar-Apr;30(2):e30-2
pubmed: 23645354
PLoS One. 2013 May 31;8(5):e64404
pubmed: 23741325
Jpn J Ophthalmol. 2008 Sep-Oct;52(5):423-425
pubmed: 18991053
Head Neck Pathol. 2017 Sep;11(3):306-313
pubmed: 27844410
BMJ Case Rep. 2011 Mar 15;2011:
pubmed: 22698907
J Pathol. 2017 Feb;241(3):405-419
pubmed: 27925203
Histopathology. 2016 Feb;68(3):422-32
pubmed: 26114478
J Clin Pathol. 2015 Jun;68(6):484-7
pubmed: 25710705
Ophthalmology. 1990 May;97(5):620-4
pubmed: 2342807
Intern Med. 2012;51(12):1635-8
pubmed: 22728506
Breast J. 2006 Jan-Feb;12(1):75-6
pubmed: 16409592
Can J Ophthalmol. 2006 Feb;41(1):93-6
pubmed: 16462881
Biomed Res Int. 2019 Jul 15;2019:2098749
pubmed: 31392209
Clin Exp Ophthalmol. 2006 Apr;34(3):239-44
pubmed: 16671904
Breast J. 2000 May;6(3):204-208
pubmed: 11348366
Ophthalmology. 1998 Oct;105(10):1897-901
pubmed: 9787361
Front Oncol. 2018 Aug 30;8:348
pubmed: 30214894
Surv Ophthalmol. 2019 Nov - Dec;64(6):741-756
pubmed: 31276737
Cancer. 2010 Oct 1;116(19):4463-73
pubmed: 20572042
J Assoc Physicians India. 2007 Jun;55:451-2
pubmed: 17879503