Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2.
COVID-19
SARS-CoV-2
antibodies
sex-related differences
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
17 09 2021
17 09 2021
Historique:
received:
15
12
2020
accepted:
04
03
2021
pubmed:
12
3
2021
medline:
30
9
2021
entrez:
11
3
2021
Statut:
ppublish
Résumé
We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m2. At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.
Identifiants
pubmed: 33693749
pii: 6161322
doi: 10.1093/infdis/jiab127
pmc: PMC7989436
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
Spike Glycoprotein, Coronavirus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
983-988Subventions
Organisme : SeroCoV-HUS
ID : PRI 7782
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE17-0028
Organisme : Laboratoire d'Excellence
ID : ANR-11-LABX-0070_TRANSPLANTEX
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : UMR_S 1109
Organisme : Institut Pasteur, Urgence COVID-19 Fundraising Campaign of Institut Pasteur, ANRS, Sidaction
Organisme : Vaccine Research Institute
ID : ANR-10-LABX-77
Organisme : Labex IBEID
ID : ANR-10-LABX-62-IBEID
Organisme : TIMTAMDEN
ID : ANR-14-CE14-0029
Organisme : CHIKV-Viro-Immuno
ID : ANR-14-CE14-0015-01
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.