The pro-inflammatory microRNA miR-155 influences fibrillar β-Amyloid
catabolism
fibrillar Aβ1-42
miR-146a
miR-155
miRNAs
primary microglia
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
22
02
2021
received:
01
08
2020
accepted:
24
02
2021
pubmed:
12
3
2021
medline:
11
3
2022
entrez:
11
3
2021
Statut:
ppublish
Résumé
Microglia are the innate immune cells of the central nervous system that adopt rapid functional changes in response to Damage Associated Molecular Patterns, including aggregated β-Amyloid (Aβ) found in Alzheimer's disease (AD). microRNAs (miRNAs) are post-transcriptional modulators that influence the timing and magnitude of microglia inflammatory responses by downregulating the expression of inflammatory effectors. Recent studies implicate miR-155, a miRNA known to regulate inflammatory responses, in the pathogenesis of neurodegenerative disorders including multiple sclerosis, ALS, familial Parkinson's disease, and AD. In this work, we asked if miR-155 expression in microglia modifies cellular behaviors in response to fibrillar Aβ
Identifiants
pubmed: 33694209
doi: 10.1002/glia.23988
pmc: PMC9098129
mid: NIHMS1799132
doi:
Substances chimiques
Amyloid beta-Peptides
0
Lipopolysaccharides
0
MIRN155 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1736-1748Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM095421
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051437
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052354
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073848
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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