A population-based study of head injury, cognitive function and pathological markers.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
04
02
2021
accepted:
12
02
2021
pubmed:
12
3
2021
medline:
12
1
2022
entrez:
11
3
2021
Statut:
ppublish
Résumé
To assess associations between head injury (HI) with loss of consciousness (LOC), ageing and markers of later-life cerebral pathology; and to explore whether those effects may help explain subtle cognitive deficits in dementia-free individuals. Participants (n = 502, age = 69-71) from the 1946 British Birth Cohort underwent cognitive testing (subtests of Preclinical Alzheimer Cognitive Composite), Compared to those with no evidence of an LOC HI, only those reporting an LOC HI>15 years prior (16%, n = 80) performed worse on cognitive tests at age 69-71, taking into account premorbid cognition, particularly on the digit-symbol substitution test (DSST). Smaller brain volume (BV) and adverse NAWM microstructural integrity explained 30% and 16% of the relationship between HI and DSST, respectively. We found no evidence that LOC HI was associated with Aβ load, hippocampal volume, WMH volume, AD-related cortical thickness or NFL (all p > 0.01). Having a LOC HI aged 50's and younger was linked with lower later-life cognitive function at age ~70 than expected. This may reflect a damaging but small impact of HI; explained in part by smaller BV and different microstructure pathways but not via pathology related to AD (amyloid, hippocampal volume, AD cortical thickness) or ongoing neurodegeneration (serum NFL).
Identifiants
pubmed: 33694298
doi: 10.1002/acn3.51331
pmc: PMC8045921
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-856Subventions
Organisme : Alzheimer's Society UK
ID : AS-JF-17-011
Organisme : Medical Research Council
ID : MC_UU_12019/3
Pays : United Kingdom
Organisme : Medical Research Council Dementias Platform UK
ID : CSUB19166
Organisme : Wellcome Trust
ID : 200109/Z/15/Z
Pays : United Kingdom
Organisme : Alzheimer's Society UK
ID : AS-PG-15-025
Organisme : Alzheimer's Research UK
ID : ARUK-PG2017-1946
Organisme : Alzheimer's Research UK
ID : ARUK-PG2014-1946
Organisme : Medical Research Council
ID : MC_UU_00019/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12019/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Alzheimer's Society UK
ID : ARUK-SRF2013-8
Organisme : Medical Research Council
ID : MR/J01107X/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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