Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility.
composite
compression
extracellular matrix
mechanical stress
mouse
multicellular aggregates
physics of living systems
poro-active
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 03 2021
11 03 2021
Historique:
received:
19
09
2020
accepted:
08
03
2021
pubmed:
12
3
2021
medline:
15
12
2021
entrez:
11
3
2021
Statut:
epublish
Résumé
Imposed deformations play an important role in morphogenesis and tissue homeostasis, both in normal and pathological conditions. To perceive mechanical perturbations of different types and magnitudes, tissues need appropriate detectors, with a compliance that matches the perturbation amplitude. By comparing results of selective osmotic compressions of CT26 mouse cells within multicellular aggregates and global aggregate compressions, we show that global compressions have a strong impact on the aggregates growth and internal cell motility, while selective compressions of same magnitude have almost no effect. Both compressions alter the volume of individual cells in the same way over a shor-timescale, but, by draining the water out of the extracellular matrix, the global one imposes a residual compressive mechanical stress on the cells over a long-timescale, while the selective one does not. We conclude that the extracellular matrix is as a sensor that mechanically regulates cell proliferation and migration in a 3D environment.
Identifiants
pubmed: 33704063
doi: 10.7554/eLife.63258
pii: 63258
pmc: PMC8064752
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021, Dolega et al.
Déclaration de conflit d'intérêts
MD, SM, BB, JJ, PR, GC No competing interests declared
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