The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1

Animals Genetic Background Kidney Mice Mice, Inbred C57BL Mutation Polycystic Kidney, Autosomal Dominant / genetics TRPP Cation Channels / genetics
ADPKD PKD1 animal models disease modifiers preclinical testing

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
06 2021
Historique:
received: 17 09 2020
revised: 14 01 2021
accepted: 21 01 2021
pubmed: 12 3 2021
medline: 25 6 2021
entrez: 11 3 2021
Statut: ppublish

Résumé

Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2 mutations, causes progressive kidney cyst development and kidney failure. There is significant intrafamilial variability likely due to the genetic background and environmental/lifestyle factors; variability that can be modeled in PKD mice. Here, we characterized mice homozygous for the PKD1 hypomorphic allele, p.Arg3277Cys (Pkd1

Identifiants

DOI: 10.1016/j.kint.2021.01.028 PMID: 33705824 PMC: PMC9107297
pubmed: 33705824
pii: S0085-2538(21)00259-3
doi: 10.1016/j.kint.2021.01.028
pmc: PMC9107297
mid: NIHMS1681421
pii:
doi:

Substances chimiques

TRPP Cation Channels 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1392-1407

Subventions

Organisme : NIDDK NIH HHS
ID : F31 DK105778
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK090728
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK058816
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007013
Pays : United States

Informations de copyright

Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

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Auteurs

Jennifer Arroyo (J)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Diana Escobar-Zarate (D)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Harrison H Wells (HH)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Megan M Constans (MM)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Ka Thao (K)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Jessica M Smith (JM)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Cynthia J Sieben (CJ)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Madeline R Martell (MR)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Timothy L Kline (TL)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Maria V Irazabal (MV)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Vicente E Torres (VE)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Katharina Hopp (K)

Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: katharina.hopp@cuanschutz.edu.

Peter C Harris (PC)

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: Harris.peter@mayo.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The genetic background significantly impacts...
questionsmedicales.fr › Phénomènes génétiques › Contexte génétique › The genetic background significantly impacts...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › The genetic background significantly impacts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The genetic background significantly impacts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The genetic background significantly impacts...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The genetic background significantly impacts...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Ciliopathies › Polykystoses rénales › Polykystose rénale autosomique dominante › The genetic background significantly impacts...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPP › The genetic background significantly impacts...