Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India.
Adolescent
Adult
Aged
Antibodies, Neutralizing
/ analysis
Antibodies, Viral
/ analysis
B-Lymphocytes
/ cytology
COVID-19
/ epidemiology
Humans
Immunity, Humoral
Immunoglobulin Isotypes
/ analysis
India
/ epidemiology
Male
Middle Aged
Pandemics
Spike Glycoprotein, Coronavirus
/ immunology
Young Adult
COVID-19
India
Memory B cells
Neutralizing antibodies
Receptor binding domain
SARS-CoV-2
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
14
10
2020
accepted:
12
02
2021
pubmed:
12
3
2021
medline:
22
4
2021
entrez:
11
3
2021
Statut:
ppublish
Résumé
India is one of the most affected countries by COVID-19 pandemic; but little is understood regarding immune responses to SARS-CoV-2 in this region. Herein we examined SARS-CoV-2 neutralizing antibodies, IgG, IgM, IgA and memory B cells in COVID-19 recovered individual from India. While a vast majority of COVID-19 recovered individuals showed SARS-CoV-2 RBD-specific IgG, IgA and IgM antibodies (38/42, 90.47%; 21/42, 50%; 33/42, 78.57% respectively), only half of them had appreciable neutralizing antibody titers. RBD-specific IgG, but not IgA or IgM titers, correlated with neutralizing antibody titers and RBD-specific memory B cell frequencies. These findings have timely significance for identifying potential donors for plasma therapy using RBD-specific IgG assays as surrogate measurement for neutralizing antibodies in India. Further, this study provides useful information needed for designing large-scale studies towards understanding of inter-individual variation in immune memory to SARS CoV-2 natural infection for future vaccine evaluation and implementation efforts.
Identifiants
pubmed: 33706207
pii: S0042-6822(21)00036-2
doi: 10.1016/j.virol.2021.02.002
pmc: PMC7934698
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Immunoglobulin Isotypes
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-21Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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