Bronchiolitis and SARS-CoV-2.
Bronchiolitis
/ epidemiology
COVID-19
/ diagnosis
COVID-19 Testing
/ methods
Causality
Child Health Services
/ statistics & numerical data
Comorbidity
Female
Hospitalization
/ statistics & numerical data
Humans
Infant
Italy
/ epidemiology
Male
SARS-CoV-2
/ isolation & purification
Severity of Illness Index
COVID-19
epidemiology
virology
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
05
11
2020
revised:
01
02
2021
accepted:
25
02
2021
pubmed:
13
3
2021
medline:
28
9
2021
entrez:
12
3
2021
Statut:
ppublish
Résumé
It has been speculated that the SARS-CoV-2 was already widespread in western countries before February 2020. We gauged this hypothesis by analysing the nasal swab of infants with either bronchiolitis or a non-infectious disease admitted to the Ospedale Maggiore, Milan (one of the first epicentres of SARS-CoV-2 outbreak in Europe) from November 2019. The SARS-CoV-2 RNA was never detected in 218 infants with bronchiolitis (95 females, median age 4.9 months) and 49 infants (22 females, median age 5.6 months) with a non-infectious disease between November 2019 and February 2020. On the contrary, two infants hospitalised for bronchiolitis between March and April 2020 tested positive for SARS-CoV-2. This study does not support the hypothesis that SARS-CoV-2 was already circulating among infants before the official outbreak of SARS-CoV-2 infection. However, it shows for the first time that SARS-CoV-2 might cause bronchiolitis requiring hospitalisation.
Sections du résumé
BACKGROUND
BACKGROUND
It has been speculated that the SARS-CoV-2 was already widespread in western countries before February 2020.
METHODS
METHODS
We gauged this hypothesis by analysing the nasal swab of infants with either bronchiolitis or a non-infectious disease admitted to the Ospedale Maggiore, Milan (one of the first epicentres of SARS-CoV-2 outbreak in Europe) from November 2019.
RESULTS
RESULTS
The SARS-CoV-2 RNA was never detected in 218 infants with bronchiolitis (95 females, median age 4.9 months) and 49 infants (22 females, median age 5.6 months) with a non-infectious disease between November 2019 and February 2020. On the contrary, two infants hospitalised for bronchiolitis between March and April 2020 tested positive for SARS-CoV-2.
CONCLUSIONS
CONCLUSIONS
This study does not support the hypothesis that SARS-CoV-2 was already circulating among infants before the official outbreak of SARS-CoV-2 infection. However, it shows for the first time that SARS-CoV-2 might cause bronchiolitis requiring hospitalisation.
Identifiants
pubmed: 33707224
pii: archdischild-2020-321108
doi: 10.1136/archdischild-2020-321108
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
999-1001Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.