Elevated levels of mitochondrial CoQ
Animals
Apoptosis
Cell Line, Tumor
Cell Proliferation
Cell Respiration
Cell Survival
Electron Transport Complex II
/ metabolism
Glycerol-3-Phosphate Dehydrogenase (NAD+)
Humans
Membrane Potential, Mitochondrial
Mice, Nude
Mitochondria
/ metabolism
Organoids
/ pathology
Oxidative Stress
Oxygen Consumption
Pancreatic Neoplasms
/ metabolism
Reactive Oxygen Species
/ metabolism
Substrate Specificity
Ubiquinone
/ analogs & derivatives
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 03 2021
11 03 2021
Historique:
received:
31
08
2020
accepted:
22
02
2021
entrez:
12
3
2021
pubmed:
13
3
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for targeting ROS pathways for effective anti-cancer therapeutics. Coenzyme Q
Identifiants
pubmed: 33707480
doi: 10.1038/s41598-021-84852-z
pii: 10.1038/s41598-021-84852-z
pmc: PMC7952582
doi:
Substances chimiques
Reactive Oxygen Species
0
Ubiquinone
1339-63-5
Glycerol-3-Phosphate Dehydrogenase (NAD+)
EC 1.1.1.8
Electron Transport Complex II
EC 1.3.5.1
coenzyme Q10
EJ27X76M46
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5749Références
J Biol Chem. 2011 Aug 5;286(31):27103-10
pubmed: 21659507
Cancer Res. 2013 Jan 1;73(1):50-61
pubmed: 23135917
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Biochem J. 1992 May 15;284 ( Pt 1):1-13
pubmed: 1599389
J Immunol Methods. 2005 Nov 30;306(1-2):68-79
pubmed: 16256133
Mol Biotechnol. 2007 Sep;37(1):31-7
pubmed: 17914161
J Biol Chem. 2002 Nov 22;277(47):44784-90
pubmed: 12237311
Free Radic Biol Med. 2016 Nov;100:14-31
pubmed: 27085844
Biochim Biophys Acta. 2013 Mar;1827(3):401-10
pubmed: 23220394
Front Oncol. 2020 Feb 28;10:256
pubmed: 32185131
FEBS Lett. 1999 Jul 9;454(3):173-6
pubmed: 10431801
Mitochondrion. 2007 Jun;7 Suppl:S51-61
pubmed: 17482887
Redox Biol. 2013 May 23;1:304-12
pubmed: 24024165
Nat Med. 2015 Nov;21(11):1364-71
pubmed: 26501191
Trends Cell Biol. 2016 May;26(5):367-378
pubmed: 26827090
Cell Rep. 2016 Apr 5;15(1):197-209
pubmed: 27052170
Apoptosis. 2017 Nov;22(11):1321-1335
pubmed: 28936716
Toxicol In Vitro. 2020 Jun;65:104788
pubmed: 32027944
PLoS One. 2012;7(3):e33712
pubmed: 22432044
Cell Metab. 2016 Apr 12;23(4):725-34
pubmed: 27076081
Cell Cycle. 2011 Dec 1;10(23):4047-64
pubmed: 22134189
Curr Biol. 2014 May 19;24(10):R453-62
pubmed: 24845678
Nat Rev Drug Discov. 2009 Jul;8(7):579-91
pubmed: 19478820
Mol Syndromol. 2014 Jul;5(3-4):163-9
pubmed: 25126049
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Cytometry. 1999 Apr 1;35(4):311-7
pubmed: 10213196
FEBS Lett. 1975 Nov 15;59(2):137-9
pubmed: 1227927
Biochim Biophys Acta. 2016 Jul;1857(7):991-1000
pubmed: 26820434
Cancer Metab. 2014 Nov 28;2:17
pubmed: 25671107
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4410-7
pubmed: 26216984
Oncotarget. 2015 Jul 10;6(19):16832-47
pubmed: 26164081
Sci Transl Med. 2014 Jan 29;6(221):221ra15
pubmed: 24477002
Lipids. 2018 Jan;53(1):133-142
pubmed: 29488636
Biochim Biophys Acta. 1957 Jul;25(1):220-1
pubmed: 13445756