From arteries to capillaries: approaches to engineering human vasculature.
Tissue engineering
engineered microvasculature
tissue engineered blood vessels
tissue vascularization
Journal
Advanced functional materials
ISSN: 1616-301X
Titre abrégé: Adv Funct Mater
Pays: Germany
ID NLM: 101190390
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
entrez:
12
3
2021
pubmed:
13
3
2021
medline:
13
3
2021
Statut:
ppublish
Résumé
From micro-scaled capillaries to millimeter-sized arteries and veins, human vasculature spans multiple scales and cell types. The convergence of bioengineering, materials science, and stem cell biology has enabled tissue engineers to recreate the structure and function of different hierarchical levels of the vascular tree. Engineering large-scale vessels has been pursued over the past thirty years to replace or bypass damaged arteries, arterioles, and venules, and their routine application in the clinic may become a reality in the near future. Strategies to engineer meso- and microvasculature have been extensively explored to generate models to study vascular biology, drug transport, and disease progression, as well as for vascularizing engineered tissues for regenerative medicine. However, bioengineering of large-scale tissues and whole organs for transplantation, have failed to result in clinical translation due to the lack of proper integrated vasculature for effective oxygen and nutrient delivery. The development of strategies to generate multi-scale vascular networks and their direct anastomosis to host vasculature would greatly benefit this formidable goal. In this review, we discuss design considerations and technologies for engineering millimeter-, meso-, and micro-scale vessels. We further provide examples of recent state-of-the-art strategies to engineer multi-scale vasculature. Finally, we identify key challenges limiting the translation of vascularized tissues and offer our perspective on future directions for exploration.
Identifiants
pubmed: 33708027
doi: 10.1002/adfm.201910811
pmc: PMC7942836
mid: NIHMS1664579
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL120046
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027062
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA249799
Pays : United States
Organisme : NIBIB NIH HHS
ID : UH3 EB025765
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL076485
Pays : United States
Organisme : NIBIB NIH HHS
ID : UG3 EB025765
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no conflict of interest.
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