Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension.
2K1C Goldblatts’ model
ACE2 (angiotensin converting Enzyme-2)
angiotensin II (A II) receptor antagonists
chronic kidney
hypertension
neprilysin (NEP)
renin angiotensin aldestron system
urinary bio markers
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
09
2020
accepted:
29
12
2020
entrez:
12
3
2021
pubmed:
13
3
2021
medline:
13
3
2021
Statut:
epublish
Résumé
Activation of the renin angiotensin system plays a pivotal role in the regulation of blood pressure, which is mainly attributed to the formation of angiotensin-II (Ang II). The actions of Ang II are mediated through binding to the Ang-II type 1 receptor (AT1R) which leads to increased blood pressure, fluid retention, and aldosterone secretion. In addition, Ang II is also involved in cell injury, vascular remodeling, and inflammation. The actions of Ang II could be antagonized by its conversion to the vasodilator peptide Ang (1-7), partly generated by the action of angiotensin converting enzyme 2 (ACE2) and/or neprilysin (NEP). Previous studies demonstrated increased urinary ACE2 shedding in the
Identifiants
pubmed: 33708117
doi: 10.3389/fphar.2020.602985
pii: 602985
pmc: PMC7941277
doi:
Types de publication
Journal Article
Langues
eng
Pagination
602985Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK093226
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL093567
Pays : United States
Informations de copyright
Copyright © 2021 Alawi, Dhakal, Emberesh, Sawant, Hosawi, Thanekar, Grobe and Elased.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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