Strategy to enhance dendritic cell-mediated DNA vaccination in the lung.
adaptive immunity
airway mucus
nanoparticle
pulmonary DNA vaccination
Journal
Advanced therapeutics
ISSN: 2366-3987
Titre abrégé: Adv Ther (Weinh)
Pays: Germany
ID NLM: 101724632
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
entrez:
12
3
2021
pubmed:
13
3
2021
medline:
13
3
2021
Statut:
ppublish
Résumé
We here introduce a new paradigm to promote pulmonary DNA vaccination. Specifically, we demonstrate that nanoparticles designed to rapidly penetrate airway mucus (mucus-penetrating particle or MPP) enhance the delivery of inhaled model DNA vaccine (i.e. ovalbumin-expressing plasmids) to pulmonary dendritic cells (DC), leading to robust and durable local and trans-mucosal immunity. In contrast, mucus-impermeable particles were poorly taken up by pulmonary DC following inhalation, despite their superior ability to mediate DC uptake
Identifiants
pubmed: 33709020
doi: 10.1002/adtp.202000228
pmc: PMC7941873
mid: NIHMS1622101
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NEI NIH HHS
ID : P30 EY001765
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127413
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136617
Pays : United States
Déclaration de conflit d'intérêts
Competing interests: The mucus-penetrating particle technology described in this publication is being developed by Kala Pharmaceuticals. Justin Hanes is a co-founder of Kala. He owns company stock, which is subject to certain restrictions under Johns Hopkins University policy. The terms of this arrangement are being managed by Johns Hopkins University in accordance with its conflict of interest policies.
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