Organelle stress and glycation in kidney disease.
Endoplasmic reticulum stress
Mitochondrial stress
Organelle stress
Oxidative stress
Tubular inflammation
Journal
Glycoconjugate journal
ISSN: 1573-4986
Titre abrégé: Glycoconj J
Pays: United States
ID NLM: 8603310
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
23
01
2021
accepted:
28
02
2021
revised:
23
01
2021
pubmed:
13
3
2021
medline:
5
3
2022
entrez:
12
3
2021
Statut:
ppublish
Résumé
Glycation of proteins is a non-enzymatic posttranslational modification. Such random modification often deranges the structure and function of a wide range of proteins, and in turn leads to cellular dysfunction and organ damage. Protein glycation is thus an important topic in understanding the molecular mechanisms of the development or progression of various kinds of diabetes-related diseases. Meanwhile, organelle stress, such as mitochondrial or endoplasmic reticulum (ER) damage, is a causal factor for cellular dysfunction. Under pathogenic conditions, mitochondrial stress and ER stress are induced by glycated proteins. Intensive research has revealed the molecular mechanism of how glycation contributes to cell fate via organelle stress. This article will summarize the most recent evidence on organelle stress and glycation in kidney disease, especially diabetic kidney disease (DKD) associated with high glycation status.
Identifiants
pubmed: 33709200
doi: 10.1007/s10719-021-09989-5
pii: 10.1007/s10719-021-09989-5
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
341-346Références
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