Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents.
Adolescent depression
Enjoyment
Exercise
Motivation
Physical activity
Placebo
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
20
10
2020
accepted:
08
02
2021
pubmed:
13
3
2021
medline:
4
8
2022
entrez:
12
3
2021
Statut:
ppublish
Résumé
Recent meta-analyses reveal a moderate effect of physical activity (PA) in the treatment of adolescent depression. However, not only the underlying neurobiological mechanisms, also the influences of placebo-related motivational factors (beliefs and expectancies in sporting, enjoyment and prior sports experiences), are still unclear. Based on the data of our prior study "Mood Vibes", we hypothesized that placebo-inherent factors like positive prior sports experiences and motivational factors, (positive beliefs, expectancies, and enjoyment related to PA), would increase the effects of an add-on exercise-therapy in juvenile depression. From 64 included depressed adolescents, 41 underwent an intensive add-on PA-therapy. Motivational factors were assessed using sport-specific scales. The changes in depression scores under treatment were rated by self-rating scale (German "Childhood Depression Inventory", (DIKJ)). A mixed model for repeated measures (MMRM) was used to analyze the effects of the different motivational variates on DIKJ. While prior sports experiences had no impact, motivational factors showed a significant effect on PA-induced changes in DIKJ scores (p = 0.002). The demotivated participants improved less, whereas it was sufficient to be neutral towards sporting to benefit significantly more. Motivational placebo-related factors (beliefs, expectancies and enjoyment regarding PA) affected the outcomes of an exercise treatment in depressed adolescents. Yet, a neutral mindset was sufficient to profit more from PA. Prior sporting in the sense of positive conditioning and as a protective factor did not play a role. Knowledge about these influences could in a second step help to develop tailored therapies.
Identifiants
pubmed: 33709258
doi: 10.1007/s00787-021-01742-5
pii: 10.1007/s00787-021-01742-5
pmc: PMC9343287
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-14Informations de copyright
© 2021. The Author(s).
Références
WHO (2018) Adolescent mental health. In: https://www.who.int/news-room/fact-sheets/detail/adolescent-mental-health . Accessed 19 Feb 2021
Costello EJ, Foley DL, Angold A (2006) 10-year research update review: the epidemiology of child and adolescent psychiatric disorders: II. Developmental epidemiology. J Am Acad Child Adolesc Psychiatry 45:8–25
pubmed: 16327577
doi: 10.1097/01.chi.0000184929.41423.c0
Jane Costello E, Erkanli A, Angold A (2006) Is there an epidemic of child or adolescent depression? J Child Psychol Psychiatry 47:1263–1271
pubmed: 17176381
Bettge S, Wille N, Barkmann C, Schulte-Markwort M, Ravens-Sieberer U (2008) Depressive symptoms of children and adolescents in a German representative sample: results of the BELLA study. Eur Child Adolesc Psychiatry 17(Suppl 1):71–81
pubmed: 19132306
doi: 10.1007/s00787-008-1008-x
Carli V, Hoven CW, Wasserman C, Chiesa F, Guffanti G, Sarchiapone M, Apter A, Balazs J, Brunner R, Corcoran P, Cosman D, Haring C, Iosue M, Kaess M, Kahn JP, Keeley H, Postuvan V, Saiz P, Varnik A, Wasserman D (2014) A newly identified group of adolescents at “invisible” risk for psychopathology and suicidal behavior: findings from the SEYLE study. World Psychiatry 13:78–86
pubmed: 24497256
pmcid: 3918027
doi: 10.1002/wps.20088
Herpertz-Dahlmann B, Buhren K, Remschmidt H (2013) Growing up is hard: mental disorders in adolescence. Dtsch Arztebl Int 110:432–439 (quiz 440)
pubmed: 23840288
pmcid: 3705204
Dolle K, Schulte-Korne G (2013) The treatment of depressive disorders in children and adolescents. Dtsch Arztebl Int 110:854–860
APA (2010) Practice guideline for the treatment of patients with major depressive disorder, 3rd edn. American Psychiatry Association
NICE (2019) Depression in children and young people: identification and management. In: National Institute for Health and Care Excellence (ed) NICE guideline [NG134]. https://www.nice.org.uk/guidance/ng134 . Accessed 19 Feb 2021
Emslie G, Kratochvil C, Vitiello B, Silva S, Mayes T, McNulty S, Weller E, Waslick B, Casat C, Walkup J, Pathak S, Rohde P, Posner K, March J, Columbia suicidality classification G, Team T (2006) Treatment for adolescents with depression study (TADS): safety results. J Am Acad Child Adolesc Psychiatry 45:1440–1455
pubmed: 17135989
pmcid: 3285253
doi: 10.1097/01.chi.0000240840.63737.1d
Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, McMurdo M, Mead GE (2013) Exercise for depression. Cochrane Database Syst Rev 9:CD004366
Oberste M, Medele M, Javelle F, Lioba Wunram H, Walter D, Bloch W, Bender S, Fricke O, Joisten N, Walzik D, Großbheinrich N, Zimmer P. Physical activity for the treatment of adolescent depression: a systematic review and meta-analysis. Front Physiol. 2020;11:185. doi: 10.3389/fphys.2020.00185.
Morral A, Urrutia G, Bonfill X (2017) Placebo effect and therapeutic context: A challenge in clinical research. Med Clin (Barc) 149:26–31
doi: 10.1016/j.medcli.2017.03.034
Lindheimer JB, O’Connor PJ, Dishman RK (2015) Quantifying the placebo effect in psychological outcomes of exercise training: a meta-analysis of randomized trials. Sports Med 45:693–711
pubmed: 25762083
doi: 10.1007/s40279-015-0303-1
Weimer K, Gulewitsch MD, Schlarb AA, Schwille-Kiuntke J, Klosterhalfen S, Enck P (2013) Placebo effects in children: a review. Pediatr Res 74:96–102
pubmed: 23598811
doi: 10.1038/pr.2013.66
Rheims S, Cucherat M, Arzimanoglou A, Ryvlin P (2008) Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy. PLoS Med 5:e166
pubmed: 18700812
pmcid: 2504483
doi: 10.1371/journal.pmed.0050166
Bridge JA, Birmaher B, Iyengar S, Barbe RP, Brent DA (2009) Placebo response in randomized controlled trials of antidepressants for pediatric major depressive disorder. Am J Psychiatry 166:42–49
pubmed: 19047322
doi: 10.1176/appi.ajp.2008.08020247
Beecher HK (1955) The powerful placebo. J Am Med Assoc 159:1602–1606
pubmed: 13271123
doi: 10.1001/jama.1955.02960340022006
Hróbjartsson A, Gøtzsche PC. Placebo interventions for all clinical conditions. Cochrane Database Syst Rev. 2010;2010(1):CD003974. doi: 10.1002/14651858.CD003974.pub3
Thiruchselvam T, Dozois DJA, Bagby RM, Lobo DSS, Ravindran LN, Quilty LC (2019) The role of outcome expectancy in therapeutic change across psychotherapy versus pharmacotherapy for depression. J Affect Disord 251:121–129
pubmed: 30921595
doi: 10.1016/j.jad.2019.01.046
Murray D, Stoessl AJ (2013) Mechanisms and therapeutic implications of the placebo effect in neurological and psychiatric conditions. Pharmacol Ther 140:306–318
pubmed: 23880289
doi: 10.1016/j.pharmthera.2013.07.009
Zilcha-Mano S, Brown PJ, Roose SP, Cappetta K, Rutherford BR (2019) Optimizing patient expectancy in the pharmacologic treatment of major depressive disorder. Psychol Med 49:2414-2420
Zilcha-Mano S, Roose SP, Brown PJ, Rutherford BR (2018) Not just nonspecific factors: the roles of alliance and expectancy in treatment, and their neurobiological underpinnings. Front Behav Neurosci 12:293
pubmed: 30760986
doi: 10.3389/fnbeh.2018.00293
Kirsch I (2018) Response expectancy and the placebo effect. Int Rev Neurobiol 138:81–93
pubmed: 29681336
doi: 10.1016/bs.irn.2018.01.003
Corsi N, Colloca L (2017) Placebo and nocebo effects: the advantage of measuring expectations and psychological factors. Front Psychol 8:308
pubmed: 28321201
pmcid: 5337503
doi: 10.3389/fpsyg.2017.00308
Kube T, Rief W, Glombiewski JA (2017) On the maintenance of expectations in major depression: investigating a neglected phenomenon. Front Psychol 8:9
pubmed: 28149287
pmcid: 5241292
doi: 10.3389/fpsyg.2017.00009
Weimer K, Colloca L, Enck P (2015) Placebo eff ects in psychiatry: mediators and moderators. Lancet Psychiatry 2:246–257
pubmed: 25815249
pmcid: 4370177
doi: 10.1016/S2215-0366(14)00092-3
Gaab J (2019) The placebo and its effects: a psychoneuroendocrinological perspective. Psychoneuroendocrinology 105:3–8
pubmed: 30098833
doi: 10.1016/j.psyneuen.2018.08.008
Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, Jerabek PA (2002) The functional neuroanatomy of the placebo effect. Am J Psychiatry 159:728–737
pubmed: 11986125
doi: 10.1176/appi.ajp.159.5.728
Finniss DG, Kaptchuk TJ, Miller F, Benedetti F (2010) Biological, clinical, and ethical advances of placebo effects. Lancet 375:686–695
pubmed: 20171404
pmcid: 2832199
doi: 10.1016/S0140-6736(09)61706-2
Cohen D, Deniau E, Maturana A, Tanguy ML, Bodeau N, Labelle R, Breton JJ, Guile JM (2008) Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials. PLoS ONE 3:e2632
pubmed: 18612460
pmcid: 2435626
doi: 10.1371/journal.pone.0002632
Whalley B, Hyland ME (2013) Placebo by proxy: the effect of parents’ beliefs on therapy for children’s temper tantrums. J Behav Med 36:341–346
pubmed: 22580966
doi: 10.1007/s10865-012-9429-x
Beedie CJ, Foad AJ (2009) The placebo effect in sports performance: a brief review. Sports Med 39:313–329
pubmed: 19317519
doi: 10.2165/00007256-200939040-00004
Mothes H, Leukel C, Seelig H, Fuchs R (2017) Do placebo expectations influence perceived exertion during physical exercise? PLoS ONE 12:e0180434
pubmed: 28662168
pmcid: 5491246
doi: 10.1371/journal.pone.0180434
Beedie C, Benedetti F, Barbiani D, Camerone E, Cohen E, Coleman D, Davis A, Elsworth-Edelsten C, Flowers E, Foad A, Harvey S, Hettinga F, Hurst P, Lane A, Lindheimer J, Raglin J, Roelands B, Schiphof-Godart L, Szabo A (2018) Consensus statement on placebo effects in sports and exercise: the need for conceptual clarity, methodological rigour, and the elucidation of neurobiological mechanisms. Eur J Sport Sci 18:1383–1389
pubmed: 30114971
doi: 10.1080/17461391.2018.1496144
Mothes H, Leukel C, Jo HG, Seelig H, Schmidt S, Fuchs R (2017) Expectations affect psychological and neurophysiological benefits even after a single bout of exercise. J Behav Med 40:293–306
pubmed: 27506909
doi: 10.1007/s10865-016-9781-3
Helfer SG, Elhai JD, Geers AL (2015) Affect and exercise: positive affective expectations can increase post-exercise mood and exercise intentions. Ann Behav Med 49:269–279
pubmed: 25248303
doi: 10.1007/s12160-014-9656-1
Wunram HL, Hamacher S, Hellmich M, Volk M, Janicke F, Reinhard F, Bloch W, Zimmer P, Graf C, Schonau E, Lehmkuhl G, Bender S, Fricke O (2018) Whole body vibration added to treatment as usual is effective in adolescents with depression: a partly randomized, three-armed clinical trial in inpatients. Eur Child Adolesc Psychiatry 27:645–662
pubmed: 29119301
doi: 10.1007/s00787-017-1071-2
Grimm NCI, Krämer LV (2014) Sportliche (In-)Aktivitat depressiver Patienten - Eine clusteranalytische Unterscheidung von motivationalen und volitionalen Typen. Zeitschrift fur Klinische Psychologie und Psychotherapie 43:104–111
doi: 10.1026/1616-3443/a000255
APA (2013) Diagnostic and statistical manual of mental disorders: DSM-V. American Psychiatric Association, Washington, DC
WHO (1993) ICD-10 classification of mental and behavioural disorders. World Health Organization, Genf
Wittchen H, Zaudig T (1997) Strukturiertes Klinisches Interview für DSM-IV. Hogrefe, Göttingen
Stiensmeier-Pelster J, Schürmann M, Duda K (1989) DIKJ Depressionsinventar für Kinder und Jugendliche. Hogrefe, Göttingen
Melchers P, Preuß U (2009) Kaufman Assessment Battery for Children. Pearson Assessment, Frankfurt
Petermann F, Daseking M (2010) HAWIK-IV. Huber Verlag, Bern; Petermann F, Daseking M, 2011 WISC-IV. Pearson Assessment, Frankfurt am Main
DGSP (2007) S 1- Leitlinie Vorsorgeuntersuchung im Sport. In:Deutsche Gesellschaft für Sportmedizin. http://www.dgsp.de/_downloads/allgemein/leitlinie_vorsorgeuntersuchung_4.10.2007-1-19.pdf . Accessed 29 June 2016
Kovacs M (1985) The children’s depression, inventory (CDI). Psychopharmacol Bull 21:995–998
pubmed: 4089116
Steer RA, Clark DA, Beck AT, Ranieri WF (1999) Common and specific dimensions of self-reported anxiety and depression: the BDI-II versus the BDI-IA. Behav Res Ther 37:183–190
pubmed: 9990749
doi: 10.1016/S0005-7967(98)00087-4
Graf C (2004) CHILT-FB (Children's Health InterventionaL Trial-questionnaire). In: Institut für Bewegungs- und Neurowissenschaft Deutsche Sporthochschule Köln (ed)
Sallis JF, Prochaska JJ, Taylor WC (2000) A review of correlates of physical activity of children and adolescents. Med Sci Sports Exerc 32:963–975
pubmed: 10795788
doi: 10.1097/00005768-200005000-00014
Sallis JF (2000) Overcoming inactivity in young people. Phys Sportsmed 28:31–32
pubmed: 20086594
doi: 10.3810/psm.2000.10.1245
Graf C (2015) Motivationen und Hemmnisse von Kindern und Jugendlichen in Bezug auf Sport. In: Institut für Bewegungs- und Neurowissenschaft Deutsche Sporthochschule Köln (ed)
Moore JB, Yin Z, Hanes JC, Duda J, Gutin B, Barbeau P (2009) Measuring enjoyment of physical activity in children: validation of the physical activity enjoyment scale. J Appl Sport Psychol 21:S116–S129
doi: 10.1080/10413200802593612
Abele-Brehm A, Brehm W (1986) Zur Konzeptionalisierung und Messung der Befindlichkeit. Die Entwicklung der Befindlichkeitsskalen (BFS). Diagnostica 32:209–228
Kendzierski D, De Carlo KJ (1991) physical activity enjoyment scale: two validation studies. J Sport Exerc Psychol 13:50–64
doi: 10.1123/jsep.13.1.50
Scanlan TK, Carpenter PJ, Schmidt GW, Simons JP, Keeler B (1993) An introduction to the sport commitment model. J Sport Exerc Psychol 15:1–15
doi: 10.1123/jsep.15.1.1
McCarthy PJ, Jones MV (2007) A quality study of sport enjoyment in the sampling years. Sport Psychol 21:400–416
doi: 10.1123/tsp.21.4.400
Trappe HJ, Löllgen H (2000) Leitlinien zur Ergometrie (Deutsche Ges. für Kardiologie) Zschr. f. Kardiologie
Veilleux LN, Rauch F (2010) Reproducibility of jumping mechanography in healthy children and adults. J Musculoskelet Neuronal Interact 10:256–266
Novotec (2006) Leonardo Mechanography Ground Reaction Force Platform (GRFP): getting started v4.1. Pforzheim. Novotec Medical GmbH
Semler O, Fricke O, Vezyroglou K, Stark C, Stabrey A, Schoenau E (2008) Results of a prospective pilot trial on mobility after whole body vibration in children and adolescents with osteogenesis imperfecta. Clinical Rehabilitation 22:387–394
Rauch F, Sievanen H, Boonen S, Cardinale M, Degens H, Felsenberg D, Roth J, Schoenau E, Verschueren S, Rittweger J (2010) Reporting whole-body vibration intervention studies: recommendations of the International Society of Musculoskeletal and Neuronal Interactions. J Musculoskelet Neuronal Interact 10:193–198
pubmed: 20811143
Gibbons MW (2011) Effect of Whole Body Vibration on Sterotypy of Young Children with Autism. In: Department of Health, Physical Education and Recreation. Utah State University, Logan, Utah
Szabo A (2013) Acute psychological benefits of exercise: reconsideration of the placebo effect. J Ment Health 22:449–455
pubmed: 23324013
doi: 10.3109/09638237.2012.734657
Pollo A, Carlino E, Benedetti F (2011) Placebo mechanisms across different conditions: from the clinical setting to physical performance. Philos Trans R Soc Lond B Biol Sci 366:1790–1798
pubmed: 21576136
pmcid: 3130395
doi: 10.1098/rstb.2010.0381
O’Halloran PD, Murphy GC, Webster KE (2002) Measure of beliefs about improvements in mood associated with exercise. Psychological Reports 90:834–840
pubmed: 12090515
doi: 10.2466/pr0.2002.90.3.834
Berger BG, Owen DR, Motl RW, Parks L (1998) Relationship between expectancy of psychological benefits and mood alteration in joggers. Int J Sport Psychol 29:1–16
Larun L, Nordheim LV, Ekeland E, Hagen KB, Heian F (2006) Exercise in prevention and treatment of anxiety and depression among children and young people (Review). Cochrane Database Syst Rev: CD004691
Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, McMurdo M, Mead GE (2013) Exercise for depression. Cochrane Database Syst Rev: CD004366
Harvey SB, Overland S, Hatch SL, Wessely S, Mykletun A, Hotopf M (2018) Exercise and the prevention of depression: results of the HUNT Cohort Study. Am J Psychiatry 175:28–36
pubmed: 28969440
doi: 10.1176/appi.ajp.2017.16111223
De Moor MH, Boomsma DI, Stubbe JH, Willemsen G, de Geus EJ (2008) Testing causality in the association between regular exercise and symptoms of anxiety and depression. Arch Gen Psychiatry 65:897–905
pubmed: 18678794
doi: 10.1001/archpsyc.65.8.897
Kirsch I (2019) Placebo effect in the treatment of depression and anxiety. Front Psychiatry 10:407
pubmed: 31249537
pmcid: 6584108
doi: 10.3389/fpsyt.2019.00407
Lindheimer JB, Szabo A, Raglin JS, Beedie C (2020) Advancing the understanding of placebo effects in psychological outcomes of exercise: lessons learned and future directions. Eur J Sport Sci 20:326–337
pubmed: 31215360
doi: 10.1080/17461391.2019.1632937
Pomp S, Fleig L, Schwarzer R, Lippke S (2012) Depressive symptoms interfere with post-rehabilitation exercise: outcome expectancies and experience as mediators. Psychol Health Med 17:698–708
pubmed: 22416795
doi: 10.1080/13548506.2012.661864
Crum AJ, Langer EJ (2007) Mind-set matters: exercise and the placebo effect. Psychol Sci 18:165–171
pubmed: 17425538
doi: 10.1111/j.1467-9280.2007.01867.x
Shavelson RJ, Burstein L, Keesling JW (1977) Methodological considerations in interpreting research on self-concept. J Youth Adolesc 6:295–307
pubmed: 24408458
doi: 10.1007/BF02138941
Janssen I, Leblanc AG (2010) Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Int J Behav Nutr Phys Act 7:40
pubmed: 20459784
pmcid: 2885312
doi: 10.1186/1479-5868-7-40
Donaghy ME (2007) Exercise can seriously improve your mental health: fact or fiction? Adv Physiother 9:76–88
doi: 10.1080/14038190701395838