Emerging role of 18F-FDG PET/CT in Castleman disease: a review.

Castleman disease Fluorodeoxyglucose F18 HIV Interleukin-6 Positron emission tomography/computed tomography

Journal

Insights into imaging
ISSN: 1869-4101
Titre abrégé: Insights Imaging
Pays: Germany
ID NLM: 101532453

Informations de publication

Date de publication:
11 Mar 2021
Historique:
received: 01 11 2020
accepted: 04 01 2021
entrez: 12 3 2021
pubmed: 13 3 2021
medline: 13 3 2021
Statut: epublish

Résumé

Castleman disease (CD) describes a group of rare hematologic conditions involving lymphadenopathy with characteristic histopathology and a spectrum of clinical abnormalities. CD is divided into localized or unicentric CD (UCD) and multicentric CD (MCD) by imaging. MCD is further divided based on etiological driver into human herpesvirus-8-associated MCD, POEMS-associated MCD, and idiopathic MCD. There is notable heterogeneity across MCD, but increased level of pro-inflammatory cytokines, particularly interleukin-6, is an established disease driver in a portion of patients. FDG-PET/CT can help determine UCD versus MCD, evaluate for neoplastic conditions that can mimic MCD clinico-pathologically, and monitor therapy responses. CD requires more robust characterization, earlier diagnosis, and an accurate tool for both monitoring and treatment response evaluation; FDG-PET/CT is particularly suited for this. Moving forward, future prospective studies should further characterize the use of FDG-PET/CT in CD and specifically explore the utility of global disease assessment and dual time point imaging.Trial registration ClinicalTrials.gov, NCT02817997, Registered 29 June 2016, https://clinicaltrials.gov/ct2/show/NCT02817997.

Identifiants

pubmed: 33709329
doi: 10.1186/s13244-021-00963-1
pii: 10.1186/s13244-021-00963-1
pmc: PMC7952491
doi:

Banques de données

ClinicalTrials.gov
['NCT02817997']

Types de publication

Journal Article Review

Langues

eng

Pagination

35

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL141408
Pays : United States

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Auteurs

Benjamin Koa (B)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Drexel University College of Medicine, Philadelphia, PA, USA.

Austin J Borja (AJ)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Mahmoud Aly (M)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Sayuri Padmanabhan (S)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Joseph Tran (J)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Vincent Zhang (V)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Chaitanya Rojulpote (C)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Sheila K Pierson (SK)

Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.

Mark-Avery Tamakloe (MA)

Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.

Johnson S Khor (JS)

Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.

Thomas J Werner (TJ)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

David C Fajgenbaum (DC)

Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.

Abass Alavi (A)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Mona-Elisabeth Revheim (ME)

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. mona.elisabeth.revheim@ous-hf.no.
Division of Radiology and Nuclear Medicine, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway. mona.elisabeth.revheim@ous-hf.no.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Problemveien 7, 0316, Oslo, Norway. mona.elisabeth.revheim@ous-hf.no.

Classifications MeSH