In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae.
Mycobacterium leprae
bacterial < infectious diseases
biomarkers
immune response
leprosy
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
07
01
2021
accepted:
23
02
2021
pubmed:
13
3
2021
medline:
26
10
2021
entrez:
12
3
2021
Statut:
ppublish
Résumé
Mycobacterium leprae, the causative agent of leprosy, is still actively transmitted in endemic areas reflected by the fairly stable number of new cases detected each year. Recognizing the signs and symptoms of leprosy is challenging, especially at an early stage. Improved diagnostic tools, based on sensitive and specific biomarkers, that facilitate diagnosis of leprosy are therefore urgently needed. In this review, we address the challenges that leprosy biomarker research is facing by reviewing cell types reported to be involved in host immunity to M leprae. These cell types can be associated with different possible fates of M leprae infection being either protective immunity, or pathogenic immune responses inducing nerve damage. Unraveling these responses will facilitate the search for biomarkers. Implications for further studies to disentangle the complex interplay between host responses that lead to leprosy disease are discussed, providing leads for the identification of new biomarkers to improve leprosy diagnostics.
Identifiants
pubmed: 33709405
doi: 10.1111/imr.12966
pmc: PMC8251784
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-192Informations de copyright
© 2021 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
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