Normal structural brain development in adolescents treated for perinatally acquired HIV: a longitudinal imaging study.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
pubmed:
13
3
2021
medline:
29
6
2021
entrez:
12
3
2021
Statut:
ppublish
Résumé
Cross-sectional studies, including one from our NOVICE cohort [Neurological Visual and Cognitive performance in children with treated perinatally acquired HIV (PHIV) compared with matched HIV-negative controls], have revealed that the brains of children with PHIV have lower white matter and grey matter volumes, more white matter hyperintensities (WMH) and poorer white matter integrity. This longitudinal study investigates whether these differences change over time. We approached all NOVICE participants to repeat MRI after 4.6 ± 0.3 years, measuring total white matter and grey matter volume, WMH volume and white matter integrity, obtained by T1-weighted, fluid-attenuated inversion recovery (FLAIR) and diffusion tensor imaging (DTI), respectively. We compared rates of change between groups using multivariable linear mixed effects models, adjusted for sex and age at enrolment. We investigated determinants of developmental deviation, and explored associations with cognitive development. Twenty out of 31 (65%) PHIV-positive, and 20 out of 37 (54%) HIV-negative participants underwent follow-up MRI. Groups did not significantly differ in terms of age and sex. Over time, we found no statistically different changes between groups for white matter and WMH volumes, and for white matter integrity (P > 0.1). Total grey matter volume decreased significantly less in PHIV [group∗time 10 ml, 95% confidence interval -1 to 20, P = 0.078], but this difference in rate of change lost statistical significance after additional adjustment for height (group∗time 9 ml, 95% confidence interval -2 to 20, P = 0.112). We found no HIV-associated determinants for potential reduced grey matter pruning, nor associations with cognitive development. While using long-term antiretroviral treatment, structural brain development of adolescents growing up with perinatally acquired HIV appears largely normal.
Identifiants
pubmed: 33710018
doi: 10.1097/QAD.0000000000002873
pii: 00002030-202107010-00007
pmc: PMC8183487
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1221-1228Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
Références
Patel K, Ming X, Williams PL, Robertson KR, Oleske JM, Seage GR 3rd. Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents . AIDS 2009; 23:1893–1901.
Blokhuis C, Peeters CFW, Cohen S, Scherpbier HJ, Kuijpers TW, Reiss P, et al. Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV . Sci Rep 2019; 9:8004.
Cohen S, Ter Stege JA, Geurtsen GJ, Scherpbier HJ, Kuijpers TW, Reiss P, et al. Poorer cognitive performance in perinatally HIV-infected children versus healthy socioeconomically matched controls . Clin Infect Dis 2015; 60:1111–1119.
Cohen S, Caan MW, Mutsaerts H-J, Scherpbier HJ, Kuijpers TW, Reiss P, et al. Cerebral injury in perinatally HIV-infected children compared to matched healthy controls . Neurology 2016; 86:19–27.
Giedd JN, Rapoport JL. Structural MRI of pediatric brain development: what have we learned and where are we going? . Neuron 2010; 67:728–734.
Lebel C, Beaulieu C. Longitudinal development of human brain wiring continues from childhood into adulthood . J Neurosci 2011; 31:10937–10947.
Van den Hof M, ter Haar AM, Caan MWA, Spijker R, van der Lee JH, Pajkrt D. Brain structure of perinatally HIV-infected patients on long-term treatment: a systematic review . Neurol Clin Pract 2019; 9:433–442.
Cole JH, Caan MWA, Underwood J, De Francesco D, van Zoest RA, Wit F, et al. No evidence for accelerated ageing-related brain pathology in treated HIV: longitudinal neuroimaging results from the Comorbidity in Relation to AIDS (COBRA) project . Clin Infect Dis 2018; 66:1899–1909.
Correa DG, Zimmermann N, Tukamoto G, Doring T, Ventura N, Leite SC, et al. Longitudinal assessment of subcortical gray matter volume, cortical thickness, and white matter integrity in HIV-positive patients . J Magn Reson Imaging 2016; 44:1262–1269.
van Zoest RA, Underwood J, De Francesco D, Sabin CA, Cole JH, Wit FW, et al. Structural brain abnormalities in successfully treated HIV infection: associations with disease and cerebrospinal fluid biomarkers . J Infect Dis 2017; 217:69–81.
Cohen S, Caan MW, Mutsaerts HJ, Scherpbier HJ, Kuijpers TW, Reiss P, et al. Cerebral injury in perinatally HIV-infected children compared to matched healthy controls . Neurology 2016; 86:19–27.
Van den Hof M, Ter Haar AM, Scherpbier HJ, van der Lee JH, Reiss P, Wit F, et al. Neurocognitive development in perinatally HIV-infected adolescents on long-term treatment compared to healthy matched controls: a longitudinal study . Clin Infect Dis 2020; 70:1364–1371.
R Core Team (2018). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, Available online at https://www.R-project.org/
Gogtay N, Thompson PM. Mapping gray matter development: implications for typical development and vulnerability to psychopathology . Brain Cogn 2010; 72:6–15.
Wade BSC, Valcour VG, Puthanakit T, et al. Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV . Neuroimage Clin 2019; 23:101810.
Yu X, Gao L, Wang H, Yin Z, Fang J, Chen J, et al. Neuroanatomical changes underlying vertical HIV infection in adolescents . Front Immunol 2019; 10:814.
de Leeuw FE, de Groot JC, Achten E, Oudkerk M, Ramos LM, Heijboer R, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study . J Neurol Neurosurg Psychiatry 2001; 70:9–14.
Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update . Nat Rev Neurol 2015; 11:157–165.
Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis . BMJ 2010; 341:c3666.
Hopkins RO, Beck CJ, Burnett DL, Weaver LK, Victoroff J, Bigler ED. Prevalence of white matter hyperintensities in a young healthy population . J Neuroimaging 2006; 16:243–251.
van der Land V, Hijmans CT, de Ruiter M, Mutsaerts HJ, Cnossen MH, Engelen M, et al. Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease . Br J Haematol 2015; 168:553–556.
Blackmon K, Ben-Avi E, Wang X, Pardoe HR, Di Martino A, Halgren E, et al. Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder . Neuroimage Clin 2016; 10:36–45.
Lyoo IK, Lee HK, Jung JH, Noam GG, Renshaw PF. White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders . Compr Psychiatry 2002; 43:361–368.
Ackermann C, Andronikou S, Laughton B, Kidd M, Dobbels E, Innes S, et al. White matter signal abnormalities in children with suspected HIV-related neurologic disease on early combination antiretroviral therapy . Pediatr Infect Dis J 2014; 33:e207–e212.
Marshall SW. Power for tests of interaction: effect of raising the Type I error rate . Epidemiol Perspect Innov 2007; 4:4.