Deepen into sleep and wake patterns across Alzheimer's disease phenotypes.
Alzheimer's disease
Brainstem
neuromodulatory subcortical systems
selective vulnerability
sleep
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
31
12
2020
received:
17
09
2020
accepted:
12
01
2021
pubmed:
13
3
2021
medline:
20
11
2021
entrez:
12
3
2021
Statut:
ppublish
Résumé
Although, the clinical variants of Alzheimer's disease (AD) show distinct patterns of cognitive and behavioral decline, disease progression, and neuropathological features, it is unclear if this clinical heterogeneity extends to sleep-wake patterns. Sleep and wake disturbances are frequent in typical AD, often preceding memory loss and negatively impacting the quality of life of patients and caregivers alike. Still, sleep and wake disorders are often misdiagnosed and undertreated in typical AD. Better characterization of sleep-wake features in AD clinical variants is an unmet gap of high importance because these differing patterns may require tailored treatment strategies. Moreover, as wake-promoting neurons are located in subcortical nuclei and degenerate early in typical AD, contrasting the profiles of sleep-wake patterns in typical and atypical AD aids diagnosis and brings a unique opportunity to uncover the mechanisms underlying AD clinical variants at the subcortical level and mechanisms for selective neuronal vulnerability.
Identifiants
pubmed: 33710762
doi: 10.1002/alz.12304
pmc: PMC8364869
mid: NIHMS1698421
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1403-1406Subventions
Organisme : NIA NIH HHS
ID : U01 AG057195
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG053435
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060477
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064314
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032289
Pays : United States
Informations de copyright
© 2021 the Alzheimer's Association.
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