Risk assessment of arterial allograft contamination from tissue donors colonized by Candida auris.
Arterial allograft
Candida auris
Contamination
Donor screening
Risk assessment
Tissue banking
Journal
The Journal of hospital infection
ISSN: 1532-2939
Titre abrégé: J Hosp Infect
Pays: England
ID NLM: 8007166
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
16
01
2021
revised:
03
03
2021
accepted:
03
03
2021
pubmed:
13
3
2021
medline:
19
8
2021
entrez:
12
3
2021
Statut:
ppublish
Résumé
Microbiological contamination is one of the main risks that must be controlled in tissue banking practices. For this reason, strict donor selection criteria are applied, disinfection protocols are used, and microbiological monitoring is performed at various stages. To detect Candida auris in arterial allografts and assess its origin. Data on two multi-tissue donations with positive microbiological cultures for C. auris were analysed. Risk factors for microbiological contamination were assessed at procurement, processing and post storage. C. auris was only isolated in cultures from arteries, and was not detected in cultures from cornea, musculoskeletal tissue or skin (even in the axillary-rectal sample taken from one donor). The donor's own skin was identified as the most likely source to explain the contamination of arteries by C. auris. Due to the pathogenicity of this fungus and difficulties associated with its correct identification, the implementation of measures for its detection in tissue donations is recommended.
Sections du résumé
BACKGROUND
BACKGROUND
Microbiological contamination is one of the main risks that must be controlled in tissue banking practices. For this reason, strict donor selection criteria are applied, disinfection protocols are used, and microbiological monitoring is performed at various stages.
AIM
OBJECTIVE
To detect Candida auris in arterial allografts and assess its origin.
METHODS
METHODS
Data on two multi-tissue donations with positive microbiological cultures for C. auris were analysed. Risk factors for microbiological contamination were assessed at procurement, processing and post storage.
FINDINGS
RESULTS
C. auris was only isolated in cultures from arteries, and was not detected in cultures from cornea, musculoskeletal tissue or skin (even in the axillary-rectal sample taken from one donor).
CONCLUSION
CONCLUSIONS
The donor's own skin was identified as the most likely source to explain the contamination of arteries by C. auris. Due to the pathogenicity of this fungus and difficulties associated with its correct identification, the implementation of measures for its detection in tissue donations is recommended.
Identifiants
pubmed: 33711353
pii: S0195-6701(21)00087-6
doi: 10.1016/j.jhin.2021.03.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-53Informations de copyright
Copyright © 2021 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.